Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

Table 2 Structural comparisons of predicted ancestral UCHL1 proteins

Comparison between lineages	Major change in backbone torsion angles	Major shifts in region	Critical region
Mammals Primates ancestor	Leu32-Gly40 Pro43-Ala46, Lys71-Ser76, Gln103-Gly111, Asn136, Glu149-Arg153, Gly210-Valn212	Secretion Signal motif C12- Peptidase domain C-terminal region	32–39 (Secretion Signal Motif)
Primates Simians ancestor	Ser41-Val43, Ala48-Leu50, Gln84-Gly87, Glu109-Gly111, Gly150-Asp156, Gly210-Ser215, Ala222-Ala223	C12-peptidase Domain C-Terminal region Farnesylation site	___
Simians Apes/human ancestor	Val31-Gly39 Ser41-Val42, Glu208-Ser215, Glu149-Cys152, Val154-Asn159, Glu203	Secretion Signal motif C12- Peptidase domain C Terminal region	32–39 (Secretion Signal Motif)

This table shows the effect of lineage specific substitutions on the backbone torsion angles of ancestral UCHL1 protein structures through comparisons among lineages given in first column

ISSN: 2730-7182