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Table 2 Structural comparisons of predicted ancestral UCHL1 proteins

From: Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

Comparison between lineages Major change in backbone torsion angles Major shifts in region Critical region
Mammals Primates ancestor Leu32-Gly40
Pro43-Ala46, Lys71-Ser76, Gln103-Gly111, Asn136,
Glu149-Arg153,
Gly210-Valn212
Secretion Signal motif
C12- Peptidase domain
C-terminal region
32–39 (Secretion Signal Motif)
Primates Simians ancestor Ser41-Val43, Ala48-Leu50, Gln84-Gly87, Glu109-Gly111,
Gly150-Asp156,
Gly210-Ser215,
Ala222-Ala223
C12-peptidase Domain
C-Terminal region
Farnesylation site
___
Simians Apes/human ancestor Val31-Gly39
Ser41-Val42, Glu208-Ser215, Glu149-Cys152,
Val154-Asn159,
Glu203
Secretion Signal motif
C12- Peptidase domain
C Terminal region
32–39 (Secretion Signal Motif)
  1. This table shows the effect of lineage specific substitutions on the backbone torsion angles of ancestral UCHL1 protein structures through comparisons among lineages given in first column