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Archived Comments for: Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis

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  1. Update on the specificity of HEN1

    Janusz Bujnicki, International Institute of Molecular and Cell Biology in Warsaw

    6 March 2006

    Shortly after the publication of the online version of this article, a new study was published by the Chen group, in which they demonstrated that HEN1 methylates both miRNA/miRNA* and siRNA/siRNA* duplexes in vitro with a preference for 21-24 nt RNA duplexes with 2 nt overhangs, and that it deposits the methyl group onto the 2' OH of the 3' terminal nucleotide:

    Yang Z, Ebright YW, Yu B, Chen X: HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide.

    Nucleic Acids Res. 2006, 34:667-75.

    Competing interests

    None declared