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Erratum to: No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly
BMC Evolutionary Biology volume 3, Article number: 5 (2003)
After the publication of this work , we became aware of the fact that the Saccharomyces cerevisiae physical interaction table from the MIPS database that was used to count the number of protein-protein interactions per S. cerevisiae protein contains numerous redundant entries http://mips.gsf.de/proj/yeast/tables/interaction/physical_interact.html. These redundancies were not removed initially, and as a result the numbers of protein-protein interactions reported for S. cerevisiae proteins and compared to the proteins' evolutionary rates were artifactually high. These redundancies have now been removed and the data has been re-analyzed. Here we briefly present the results of the re-analysis with the corrected data sets along with revisions of the relevant tables and figures.
Removal of redundant entries resulted in a substantial decrease in the number of protein-protein interactions per S. cerevisiae protein (Figure 1). However, consideration of this revised data with respect to evolutionary rates does not result in any qualitative change in the results or conclusions of our previous report. A total of 2,807 pairs of orthologous proteins, one from S. cerevisiae and one from S. pombe, were identified, and for 1,061 of these, there was data on protein-protein interactions of the S. cerevisiae member in the corrected MIPS data. There appears to be no simple dependence between protein evolution rate and the number of protein-protein interactions; in fact, the slight negative correlation between the number of interactions and the evolutionary rates is no longer statistically significant with the corrected data (Figure 1 and Table 1). There is no significant correlation between the taxonomic distribution of S. cerevisiae orthologs and the number of protein-protein interactions (r2 = 0.0004, p = 0.5). The apparent trend whereby the most prolific S. cerevisiae interactors have, on average, lower evolutionary rates than proteins that are involved in fewer protein-protein interactions also remains (Figure 2 and Table 2).
We regret any inconvenience that this inaccuracy in the data used for the original analysis might have caused. We wish to thank Dr. Hunter B. Fraser for bringing this matter to our attention.
Jordan IK, Wolf YI, Koonin EV: No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly. BMC Evol Biol. 2003, 3: 1-10.1186/1471-2148-3-1.
The online version of the original article can be found at 10.1186/1471-2148-3-1
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Jordan, I.K., Wolf, Y.I. & Koonin, E.V. Erratum to: No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly. BMC Evol Biol 3, 5 (2003). https://doi.org/10.1186/1471-2148-3-5