Moscoso LS: Horses and Tack. Chagras: Ecuadors Andean Coyboys. Edited by: Oxford P, Bish R, Quito EC. 2004, Imprenta Mariscal, Quito Ecuador: The Nature Conservancy, 61-90.
Google Scholar
Luteyn JL: Paramos: Why Study Them?. Páramo an Andean Ecosyst Under Hum Influ. Edited by: Balslev H, Luteyn JL. 1992, San Diego, CA, USA: Academic Press, 1-14.
Google Scholar
Simpson GG: Splendid Isolation: The Curious History of South American Mammals. 1980, New Haven, CT: New Haven Yale University Press
Google Scholar
McFadden B: Fossil Horses. 1992, Cambridge: Cambridge University Press
Google Scholar
Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins PA, Shianna KV, Tam SC, Tsering N, Veeramah KR, Wang W, Wangdui P, Weale ME, Xu Y, Xu Z, Yang L, Zaman MJ, Zeng C, Zhang L, Zhang X, Zhaxi P, Zheng YT: Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A. 2010, 107: 11459-11464. 10.1073/pnas.1002443107.
Article
CAS
PubMed Central
PubMed
Google Scholar
Peng Y, Yang Z, Zhang H, Cui C, Qi X, Luo X, Tao X, Wu T, Chen H, Shi H, Su B, Basang , Ouzhuluobu , Danzengduojie , Ciwangsangbu : Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol Biol Evol. 2011, 28: 1075-1081. 10.1093/molbev/msq290.
Article
CAS
PubMed
Google Scholar
Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZXP, Pool JE, Xu X, Jiang H, Vinckenbosch N, Korneliussen TS, Zheng HH, Liu T, He W, Li K, Luo R, Nie X, Wu H, Zhao M, Cao H, Zou J, Shan Y, Li SS, Yang Q, Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZXP, Pool JE, Xu X, et al: Sequencing of 50 human exomes reveals adaptation to high altitude. Science. 2010, 329 (Zhao M): 75-78.
Article
CAS
PubMed Central
PubMed
Google Scholar
Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R: Genetic evidence for high-altitude adaptation in Tibet. Science. 2010, 329: 72-75. 10.1126/science.1189406.
Article
CAS
PubMed
Google Scholar
Wang B, Zhang Y-B, Zhang F, Lin H, Wang X, Wan N, Ye Z, Weng H, Zhang L, Li X, Yan J, Wang P, Wu T, Cheng L, Wang J, Wang D-M, Ma X, Yu J: On the origin of Tibetans and their genetic basis in adapting high-altitude environments. PLoS One. 2011, 6: e17002-10.1371/journal.pone.0017002.
Article
CAS
PubMed Central
PubMed
Google Scholar
Bigham A, Bauchet M, Pinto D, Mao X, Akey JM, Mei R, Scherer SW, Julian CG, Wilson MJ, López Herráez D, Brutsaert T, Parra EJ, Moore LG, Shriver MD: Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet. 2010, 6: 1-14.
Article
Google Scholar
Bigham AW, Mao X, Mei R, Brutsaert T, Wilson MJ, Julian CG, Parra EJ, Akey JM, Moore LG, Shriver MD: Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum Genomics. 2009, 4: 79-90.
CAS
PubMed Central
PubMed
Google Scholar
Alkorta-Aranburu G, Beall CM, Witonsky DB, Gebremedhin A, Pritchard JK, Di Rienzo A: The genetic architecture of adaptations to high altitude in Ethiopia. PLoS Genet. 2012, 8: e1003110-10.1371/journal.pgen.1003110.
Article
CAS
PubMed Central
PubMed
Google Scholar
Petersen JL, Mickelson JR, Cothran EG, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, da Câmara Machado A, Distl O, Felicetti M, Fox-Clipsham L, Graves KT, Guérin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, Penedo MCT, Piercy RJ, Raekallio M, et al: Genetic Diversity in the Modern Horse Illustrated from Genome-Wide SNP Data. PLoS One. 2013, 8: e54997-10.1371/journal.pone.0054997.
Article
CAS
PubMed Central
PubMed
Google Scholar
Tucker RP, Chiquet-Ehrismann R: Teneurins: a conserved family of transmembrane proteins involved in intercellular signaling during development. Dev Biol. 2006, 290: 237-245. 10.1016/j.ydbio.2005.11.038.
Article
CAS
PubMed
Google Scholar
Rubin BP, Tucker RP, Brown-Luedi M, Martin D, Chiquet-Ehrismann R: Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro. Development. 2002, 129: 4697-4705.
CAS
PubMed
Google Scholar
Tucker RP, Chiquet-Ehrismann R, Chevron MP, Martin D, Hall RJ, Rubin BP: Teneurin-2 is expressed in tissues that regulate limb and somite pattern formation and is induced in vitro and in situ by FGF8. Dev Dyn. 2001, 220: 27-39. 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1084>3.0.CO;2-B.
Article
CAS
PubMed
Google Scholar
Corcoran A, O’Connor JJ: Hypoxia inducible factor signalling mechanisms in the central nervous system. Acta Physiol (Oxf). 2013, 208: 298-310. 10.1111/apha.12117.
Article
CAS
Google Scholar
Schmitz A, Demmel S, Peters LM, Leeb T, Mevissen M, Haase BLA: Comparative human-horse sequence analysis of the CYP3A subfamily gene cluster. Anim Genet. 2010, 41 (Suppl 2): 72-79.
Article
CAS
PubMed
Google Scholar
Yang W, Qi Y, Bi K, Fu J: Toward understanding the genetic basis of adaptation to high-elevation life in poikilothermic species: a comparative transcriptomic analysis of two ranid frogs, Rana chensinensis and R. kukunoris. BMC Genomics. 2012, 13: 588-10.1186/1471-2164-13-588.
Article
CAS
PubMed Central
PubMed
Google Scholar
Fradette C, Batonga J, Teng S, Piquette-Miller M, du Souich P: Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver. Drug Metab Dispos. 2007, 35: 765-771. 10.1124/dmd.106.013508.
Article
CAS
PubMed
Google Scholar
Xu S, Li S, Yang Y, Tan J, Lou H, Jin W, Yang L, Pan X, Wang J, Shen Y, Wu B, Wang H, Jin L: A genome-wide search for signals of high-altitude adaptation in Tibetans. Mol Biol Evol. 2011, 28: 1003-1011. 10.1093/molbev/msq277.
Article
PubMed
Google Scholar
Storz JF, Scott GR, Cheviron ZA: Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates. J Exp Biol. 2010, 213 (Pt 24): 4125-4136.
Article
PubMed Central
PubMed
Google Scholar
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segrè AV, Estrada K, Liang L, Nemesh J, Park J-H, Gustafsson S, Kilpeläinen TO, et al: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010, 42: 937-948. 10.1038/ng.686.
Article
CAS
PubMed Central
PubMed
Google Scholar
Vilariño-Güell C, Wider C, Ross OA, Jasinska-Myga B, Kachergus J, Cobb SA, Soto-Ortolaza AI, Behrouz B, Heckman MG, Diehl NN, Testa CM, Wszolek ZK, Uitti RJ, Jankovic J, Louis ED, Clark LN, Rajput A, Farrer MJ: LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. Neurogenetics. 2010, 11: 401-408. 10.1007/s10048-010-0241-x.
Article
PubMed Central
PubMed
Google Scholar
Wu Y-W, Prakash KM, Rong T-Y, Li H-H, Xiao Q, Tan LC, Au W-L, Ding J, Chen S, Tan E-K: Lingo2 variants associated with essential tremor and Parkinson’s disease. Hum Genet. 2011, 129: 611-615. 10.1007/s00439-011-0955-3.
Article
CAS
PubMed
Google Scholar
Zhou F, You G: Molecular insights into the structure-function relationship of organic anion transporters OATs. Pharm Res. 2007, 24: 28-36.
Article
PubMed
Google Scholar
Tang L, Xu J, Wei F, Wang L, Nie W-W, Chen L-B, Guan X-X: Association of STXBP4/COX11 rs6504950 (G>A) polymorphism with breast cancer risk: evidence from 17,960 cases and 22,713 controls. Arch Med Res. 2012, 43: 383-388. 10.1016/j.arcmed.2012.07.008.
Article
CAS
PubMed
Google Scholar
Campa D, Kaaks R, Le Marchand L, Haiman CA, Travis RC, Berg CD, Buring JE, Chanock SJ, Diver WR, Dostal L, Fournier A, Hankinson SE, Henderson BE, Hoover RN, Isaacs C, Johansson M, Kolonel LN, Kraft P, Lee I-M, McCarty CA, Overvad K, Panico S, Peeters PHM, Riboli E, Sanchez MJ, Schumacher FR, Skeie G, Stram DO, Thun MJ, Trichopoulos D, et al: Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. J Natl Cancer Inst. 2011, 103: 1252-1263. 10.1093/jnci/djr265.
Article
PubMed Central
PubMed
Google Scholar
Antoniou AC, Beesley J, McGuffog L, Sinilnikova OM, Healey S, Neuhausen SL, Ding YC, Rebbeck TR, Weitzel JN, Lynch HT, Isaacs C, Ganz PA, Tomlinson G, Olopade OI, Couch FJ, Wang X, Lindor NM, Pankratz VS, Radice P, Manoukian S, Peissel B, Zaffaroni D, Barile M, Viel A, Allavena A, Dall’Olio V, Peterlongo P, Szabo CI, Zikan M, Claes K, et al: Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Res. 2010, 70: 9742-9754. 10.1158/0008-5472.CAN-10-1907.
Article
CAS
PubMed Central
PubMed
Google Scholar
Bhatti P, Doody MM, Rajaraman P, Alexander BH, Yeager M, Hutchinson A, Burdette L, Thomas G, Hunter DJ, Simon SL, Weinstock RM, Rosenstein M, Stovall M, Preston DL, Linet MS, Hoover RN, Chanock SJ, Sigurdson AJ: Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. Radiat Res. 2010, 173: 214-224. 10.1667/RR1985.1.
Article
CAS
PubMed Central
PubMed
Google Scholar
Hiser L, Di Valentin M, Hamer AG, Hosler JP: Cox11p is required for stable formation of the Cu(B) and magnesium centers of cytochrome c oxidase. J Biol Chem. 2000, 275: 619-623. 10.1074/jbc.275.1.619.
Article
CAS
PubMed
Google Scholar
Ghorbel MT, Cherif M, Jenkins E, Mokhtari A, Kenny D, Angelini GD, Caputo M: Transcriptomic analysis of patients with tetralogy of Fallot reveals the effect of chronic hypoxia on myocardial gene expression. J Thorac Cardiovasc Surg. 2010, 140: 37–345-e26.
Article
Google Scholar
Petersen JL, Mickelson JR, Rendahl AK, Valberg SJ, Andersson LS, Axelsson J, Bailey E, Bannasch D, Binns MM, Borges AS, Brama P, da Câmara MA, Capomaccio S, Cappelli K, Cothran EG, Distl O, Fox-Clipsham L, Graves KT, Guérin G, Haase B, Hasegawa T, Hemmann K, Hill EW, Leeb T, Lindgren G, Lohi H, Lopes MS, McGivney BA, Mikko S, Orr N, et al: Genome-wide analysis reveals selection for important traits in domestic horse breeds. PLoS Genet. 2013, 9: e1003211-10.1371/journal.pgen.1003211.
Article
CAS
PubMed Central
PubMed
Google Scholar
McCue ME, Bannasch DL, Petersen JL, Gurr J, Bailey E, Binns MM, Distl O, Guérin G, Hasegawa T, Hill EW, Leeb T, Lindgren G, Penedo MCT, Røed KH, Ryder OA, Swinburne JE, Tozaki T, Valberg SJ, Vaudin M, Lindblad-Toh K, Wade CM, Mickelson JR: A high density SNP array for the domestic horse and extant Perissodactyla: utility for association mapping, genetic diversity, and phylogeny studies. PLoS Genet. 2012, 8: e1002451-10.1371/journal.pgen.1002451.
Article
CAS
PubMed Central
PubMed
Google Scholar
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, Maller J, Sklar P, de Bakker PIW, Daly MJ, Sham PC: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007, 81 (Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M A R, Bender D, Maller J, Sklar P, de Bakker PIW, Daly MJ, Sham PC): 559-575.
Article
CAS
PubMed Central
PubMed
Google Scholar
Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D: Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006, 38: 904-909. 10.1038/ng1847.
Article
CAS
PubMed
Google Scholar
Weir BS, Cardon LR, Anderson AD, Nielsen DM, Hill WG: Measures of human population structure show heterogeneity among genomic regions. Genome Res. 2005, 15: 1468-1476. 10.1101/gr.4398405.
Article
CAS
PubMed Central
PubMed
Google Scholar
Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, Lear TL, Adelson DL, Bailey E, Bellone RR, Blöcker H, Distl O, Edgar RC, Garber M, Leeb T, Mauceli E, MacLeod JN, Penedo MCT, Raison JM, Sharpe T, Vogel J, Andersson L, Antczak DF, Biagi T, Binns MM, Chowdhary BP, Coleman SJ, Della Valle G, Fryc S, Guérin G, et al: Genome sequence, comparative analysis, and population genetics of the domestic horse. Science. 2009, 326: 865-867. 10.1126/science.1178158.
Article
CAS
PubMed Central
PubMed
Google Scholar
Dreszer TR, Karolchik D, Zweig AS, Hinrichs AS, Raney BJ, Kuhn RM, Meyer LR, Wong M, Sloan CA, Rosenbloom KR, Roe G, Rhead B, Pohl A, Malladi VS, Li CH, Learned K, Kirkup V, Kirkup V, Hsu F, Harte RA, Guruvadoo L, Goldman M, Giardine BM, Fujita PA, Diekhans M, Cline MS, Clawson H, Barber GP, Haussler D, James Kent W: The UCSC Genome Browser database: extensions and updates 2011. Nucleic Acids Res. 2012, 40: D918-D923. 10.1093/nar/gkr1055. Database issue
Article
CAS
PubMed Central
PubMed
Google Scholar
Huang DW, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009, 4: 44-57.
Article
CAS
Google Scholar