Ingram CJ, Mulcare CA, Itan Y, Thomas MG, Swallow DM: Lactose digestion and the evolutionary genetics of lactase persistence. Hum Genet. 2009, 124 (6): 579-591. 10.1007/s00439-008-0593-6.
Article
CAS
PubMed
Google Scholar
Heyman MB: Lactose intolerance in infants, children, and adolescents. Pediatrics. 2006, 118 (3): 1279-1286. 10.1542/peds.2006-1721.
Article
PubMed
Google Scholar
Newcomer AD, McGill DB, Thomas PJ, Hofmann AF: Prospective comparison of indirect methods for detecting lactase deficiency. N Engl J Med. 1975, 293 (24): 1232-1236.
Article
CAS
PubMed
Google Scholar
Peuhkuri K: Lactose, lactase, and bowel disorders. 2000, Helsinki: University of Helsinki
Google Scholar
Gudmand-Hoyer E, Skovbjerg H: Disaccharide digestion and maldigestion. Scand J Gastroenterol Suppl. 1996, 216: 111-121. 10.3109/00365529609094566.
Article
CAS
PubMed
Google Scholar
Swallow DM: Genetics of lactase persistence and lactose intolerance. Annu Rev Genet. 2003, 37: 197-219. 10.1146/annurev.genet.37.110801.143820.
Article
CAS
PubMed
Google Scholar
Mulcare CA: The evolution of the lactase persistence phenotype. 2006, London: University of London
Google Scholar
Mulcare CA, Weale ME, Jones AL, Connell B, Zeitlyn D, Tarekegn A, Swallow DM, Bradman N, Thomas MG: The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans. Am J Hum Genet. 2004, 74 (6): 1102-1110. 10.1086/421050.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rasinpera H, Savilahti E, Enattah NS, Kuokkanen M, Totterman N, Lindahl H, Jarvela I, Kolho KL: A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut. 2004, 53 (11): 1571-1576. 10.1136/gut.2004.040048.
Article
PubMed Central
CAS
PubMed
Google Scholar
Swallow DM: DNA test for hypolactasia premature. Gut. 2004, 55: 131-132.
Google Scholar
Ingram CJ, Elamin MF, Mulcare CA, Weale ME, Tarekegn A, Raga TO, Bekele E, Elamin FM, Thomas MG, Bradman N, et al: A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?. Hum Genet. 2007, 120 (6): 779-788. 10.1007/s00439-006-0291-1.
Article
CAS
PubMed
Google Scholar
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen HM, Hirbo JB, Osman M, et al: Convergent adaptation of human lactase persistence in Africa and Europe. Nat Genet. 2007, 39 (1): 31-40. 10.1038/ng1946.
Article
PubMed Central
CAS
PubMed
Google Scholar
Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I: Identification of a variant associated with adult-type hypolactasia. Nat Genet. 2002, 30 (2): 233-237. 10.1038/ng826.
Article
CAS
PubMed
Google Scholar
Lewinsky RH, Jensen TG, Moller J, Stensballe A, Olsen J, Troelsen JT: T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. Hum Mol Genet. 2005, 14 (24): 3945-3953. 10.1093/hmg/ddi418.
Article
CAS
PubMed
Google Scholar
Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Jarvela I: Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut. 2003, 52 (5): 647-652. 10.1136/gut.52.5.647.
Article
PubMed Central
CAS
PubMed
Google Scholar
Olds LC, Sibley E: Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Hum Mol Genet. 2003, 12 (18): 2333-2340. 10.1093/hmg/ddg244.
Article
CAS
PubMed
Google Scholar
Wang Y, Harvey CB, Hollox EJ, Phillips AD, Poulter M, Clay P, Walker-Smith JA, Swallow DM: The genetically programmed down-regulation of lactase in children. Gastroenterology. 1998, 114 (6): 1230-1236. 10.1016/S0016-5085(98)70429-9.
Article
CAS
PubMed
Google Scholar
Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN: Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet. 2004, 74 (6): 1111-1120. 10.1086/421051.
Article
PubMed Central
CAS
PubMed
Google Scholar
Coelho M, Luiselli D, Bertorelle G, Lopes AI, Seixas S, Destro-Bisol G, Rocha J: Microsatellite variation and evolution of human lactase persistence. Hum Genet. 2005, 117 (4): 329-339. 10.1007/s00439-005-1322-z.
Article
CAS
PubMed
Google Scholar
Burger J, Kirchner M, Bramanti B, Haak W, Thomas MG: Absence of the lactase-persistence-associated allele in early Neolithic Europeans. Proc Natl Acad Sci USA. 2007, 104 (10): 3736-3741. 10.1073/pnas.0607187104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Itan Y, Powell A, Beaumont MA, Burger J, Thomas MG: The origins of lactase persistence in Europe. PLoS Comput Biol. 2009, 5 (8): e1000491-10.1371/journal.pcbi.1000491.
Article
PubMed Central
PubMed
Google Scholar
Gerbault P, Moret C, Currat M, Sanchez-Mazas A: Impact of selection and demography on the diffusion of lactase persistence. PLoS One. 2009, 4 (7): e6369-10.1371/journal.pone.0006369.
Article
PubMed Central
PubMed
Google Scholar
Enattah NS, Jensen TG, Nielsen M, Lewinski R, Kuokkanen M, Rasinpera H, El-Shanti H, Seo JK, Alifrangis M, Khalil IF, et al: Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture. Am J Hum Genet. 2008, 82 (1): 57-72. 10.1016/j.ajhg.2007.09.012.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ingram CJ, Raga TO, Tarekegn A, Browning SL, Elamin MF, Bekele E, Thomas MG, Weale ME, Bradman N, Swallow DM: Multiple Rare Variants as a Cause of a Common Phenotype: Several Different Lactase Persistence Associated Alleles in a Single Ethnic Group. Journal of Molecular Evolution. 2009, 69 (6): 579-588. 10.1007/s00239-009-9301-y.
Article
CAS
PubMed
Google Scholar
Enattah NS, Trudeau A, Pimenoff V, Maiuri L, Auricchio S, Greco L, Rossi M, Lentze M, Seo JK, Rahgozar S, et al: Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans. Am J Hum Genet. 2007, 81 (3): 615-625. 10.1086/520705.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ingram CJ: The evolutionary genetics of lactase persistence in Africa and the Middle East. 2008, London: University of London
Google Scholar
Almon R, Engfeldt P, Tysk C, Sjostrom M, Nilsson TK: Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT -13910C > T mutation. Scand J Gastroenterol. 2007, 42 (2): 165-170. 10.1080/00365520600825257.
Article
CAS
PubMed
Google Scholar
Myles S, Bouzekri N, Haverfield E, Cherkaoui M, Dugoujon JM, Ward R: Genetic evidence in support of a shared Eurasian-North African dairying origin. Hum Genet. 2005, 117 (1): 34-42. 10.1007/s00439-005-1266-3.
Article
PubMed
Google Scholar
Sibson R: A brief description of natural neighbor interpolation. Interpreting Multivariate Data (Probability & Mathematical Statistics). Edited by: Barnett V. 1981, John Wiley & Sons, 21-36.
Google Scholar
Watson D: Contouring: A Guide to the Analysis and Display of Spatial Data. 1992, Pergamon
Google Scholar
Python Programming Language. [http://www.python.org/]
Watson D: nngridr: An implementation of natural neighbour implementation. 1994, David Watson, 1:
Google Scholar
PyNGL. [http://www.pyngl.ucar.edu/]
Wand MP: Fast computation of multivariate kernel estimators. Journal of Computational and Graphical Statistics. 1994, 3: 433-445. 10.2307/1390904.
Google Scholar
Wand MP, Jones MC: Kernel Smoothing. 1994, Chapman & Hall
Google Scholar
Wand MP, Ripley B: KernSmooth. Functions for kernel smoothing for Wand & Jones (1995). 2009, [http://cran.r-project.org/web/packages/KernSmooth/index.html]
Google Scholar
Hijazi SS, Abulaban A, Ammarin Z, Flatz G: Distribution of adult lactase phenotypes in Bedouins and in urban and agricultural populations of Jordan. Tropical & Geographical Medicine. 1983, 35: 157-161.
CAS
Google Scholar
Blench R: Archaeology, Language, and the African Past. 2006, AltaMira Press, U.S.
Google Scholar
Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A, Froment A, Hirbo JB, Awomoyi AA, Bodo JM, Doumbo O, et al: The genetic structure and history of Africans and African Americans. Science. 2009, 324 (5930): 1035-1044. 10.1126/science.1172257.
Article
PubMed Central
CAS
PubMed
Google Scholar
Anagnostou P, Battaggia C, Coia V, Capelli C, Fabbri C, Pettener D, Destro-Bisol G, Luiselli D: Tracing the distribution and evolution of lactase persistence in Southern Europe through the study of the T(-13910) variant. Am J Hum Biol. 2009, 21 (2): 217-219. 10.1002/ajhb.20851.
Article
PubMed
Google Scholar
Mottes M, Belpinati F, Milani M, Saccomandi D, Petrelli E, Calacoci M, Chierici R, Pignatti PF, Borgna-Pignatti C: Genetic testing for adult-type hypolactasia in Italian families. Clin Chem Lab Med. 2008, 46 (7): 980-984. 10.1515/CCLM.2008.189.
Article
CAS
PubMed
Google Scholar
Xie HG, Kim RB, Wood AJ, Stein CM: Molecular basis of ethnic differences in drug disposition and response. Annu Rev Pharmacol Toxicol. 2001, 41: 815-850. 10.1146/annurev.pharmtox.41.1.815.
Article
CAS
PubMed
Google Scholar
Olatunbosun DA, Kwaku Adadevoh B: Lactase deficiency in Nigerians. Am J Dig Dis. 1971, 16 (10): 909-914. 10.1007/BF02238172.
Article
CAS
PubMed
Google Scholar
Arnold J, Diop M, Kodjovi M, Rozier J: L'intolerance au lactose chez l'adulte au Senegal. C R Seances Soc Biol Fil. 1980, 174: 983-992.
CAS
PubMed
Google Scholar
Bayoumi RA, Flatz SD, Kuhnau W, Flatz G: Beja and Nilotes: nomadic pastoralist groups in the Sudan with opposite distributions of the adult lactase phenotypes. Am J Phys Anthropol. 1982, 58 (2): 173-178. 10.1002/ajpa.1330580208.
Article
CAS
PubMed
Google Scholar
Cook GC, Kajubi SK: Tribal incidence of lactase deficiency in Uganda. Lancet. 1966, 1 (7440): 725-729. 10.1016/S0140-6736(66)90888-9.
Article
CAS
PubMed
Google Scholar
Sun HM, Qiao YD, Chen F, Xu LD, Bai J, Fu SB: The lactase gene -13910T allele can not predict the lactase-persistence phenotype in north China. Asia Pac J Clin Nutr. 2007, 16 (4): 598-601.
CAS
PubMed
Google Scholar
Wang YG, Yan YS, Xu JJ, Du RF, Flatz SD, Kuhnau W, Flatz G: Prevalence of primary adult lactose malabsorption in three populations of northern China. Hum Genet. 1984, 67 (1): 103-106. 10.1007/BF00270566.
Article
CAS
PubMed
Google Scholar
Swaminathan N, Mathan VI, Baker SJ, Radhakrishnan AN: Disaccharidase levels in jejunal biopsy specimens from American and south Indian control subjects and patients with tropical sprue. Clin Chim Acta. 1970, 30 (3): 707-712. 10.1016/0009-8981(70)90264-0.
Article
CAS
PubMed
Google Scholar
Yoshida Y, Sasaki G, Goto S, Yanagiya S, Takashina K: Studies on the etiology of milk intolerance in Japanese adults. Gastroenterol Jpn. 1975, 10 (1): 29-34.
CAS
PubMed
Google Scholar
Gupta PS, Misra RC, Sarin GS, Ramachandran KA, Chuttani HK: Intestinal disaccharidases activity in normal adult population in tropics. J Trop Med Hyg. 1971, 74 (10): 225-229.
CAS
PubMed
Google Scholar
Tandon RK, Joshi YK, Singh DS, Narendranathan M, Balakrishnan V, Lal K: Lactose intolerance in North and South Indians. Am J Clin Nutr. 1981, 34 (5): 943-946.
CAS
PubMed
Google Scholar
Kozlov AI: Hypolactasia in the indigenous populations of northern Russia. Int J Circumpolar Health. 1998, 57 (1): 18-21.
CAS
PubMed
Google Scholar
Jussila J: Milk intolerance and lactose malabsorption in hospital patients and young servicemen in Finland. Ann Clin Res. 1969, 1 (3): 199-207.
CAS
PubMed
Google Scholar
Ladas S, Papanikos J, Arapakis G: Lactose malabsorption in Greek adults: correlation of small bowel transit time with the severity of lactose intolerance. Gut. 1982, 23 (11): 968-973. 10.1136/gut.23.11.968.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nagy D, Bogacsi-Szabo E, Varkonyi A, Csanyi B, Czibula A, Bede O, Tari B, Rasko I: Prevalence of adult-type hypolactasia as diagnosed with genetic and lactose hydrogen breath tests in Hungarians. Eur J Clin Nutr. 2009, 63 (7): 909-912. 10.1038/ejcn.2008.74.
Article
CAS
PubMed
Google Scholar
Czeizel A, Flatz G, Flatz SD: Prevalence of primary adult lactose malabsorption in Hungary. Hum Genet. 1983, 64 (4): 398-401. 10.1007/BF00292375.
Article
CAS
PubMed
Google Scholar
Fielding JF, Harrington MG, Fottrell PF: The incidence of primary hypolactasia amongst native Irish. Ir J Med Sci. 1981, 150 (9): 276-277. 10.1007/BF02938254.
Article
CAS
PubMed
Google Scholar
Meloni T, Colombo C, Ruggiu G, Dessena M, Meloni GF: Primary lactase deficiency and past malarial endemicity in Sardinia. Ital J Gastroenterol Hepatol. 1998, 30 (5): 490-493.
CAS
PubMed
Google Scholar
Burgio GR, Flatz G, Barbera C, Patane R, Boner A, Cajozzo C, Flatz SD: Prevalence of primary adult lactose malabsorption and awareness of milk intolerance in Italy. Am J Clin Nutr. 1984, 39 (1): 100-104.
CAS
PubMed
Google Scholar
Cavalli-Sforza LT, Strata A, Barone A, Cucurachi L: Primary adult lactose malabsorption in Italy: regional differences in prevalence and relationship to lactose intolerance and milk consumption. Am J Clin Nutr. 1987, 45 (4): 748-754.
CAS
PubMed
Google Scholar
Rinaldi E, Albini L, Costagliola C, De Rosa G, Auricchio G, De Vizia B, Auricchio S: High frequency of lactose absorbers among adults with idiopathic senile and presenile cataract in a population with a high prevalence of primary adult lactose malabsorption. Lancet. 1984, 1 (8373): 355-357. 10.1016/S0140-6736(84)90409-4.
Article
CAS
PubMed
Google Scholar
Rahimi AG, Delbruck H, Haeckel R, Goedde HW, Flatz G: Persistence of high intestinal lactase activity (lactose tolerance) in Afghanistan. Hum Genet. 1976, 34 (1): 57-62. 10.1007/BF00284435.
Article
CAS
PubMed
Google Scholar
Sadre M, Karbasi K: Lactose intolerance in Iran. Am J Clin Nutr. 1979, 32 (9): 1948-1954.
CAS
PubMed
Google Scholar
Gilat T, Malachi EG, Shochet SB: Lactose tolerance in an Arab population. Am J Dig Dis. 1971, 16 (3): 203-206. 10.1007/BF02235240.
Article
CAS
PubMed
Google Scholar
Hijazi SS, Abulaban A, Ammarin Z, Flatz G: Distribution of adult lactase phenotypes in Bedouins and in urban and agricultural populations of Jordan. Trop Geogr Med. 1983, 35 (2): 157-161.
CAS
PubMed
Google Scholar
Ahmad M, Flatz G: Prevalence of primary adult lactose malabsorption in Pakistan. Hum Hered. 1984, 34 (2): 69-75. 10.1159/000153439.
Article
CAS
PubMed
Google Scholar
Dissanayake AS, Al-Quorain AA, Al-Breiki H, El-Munshid HA, Wosornu L: Prevalence of primary adult lactose malabsorption in the Eastern Region of Saudi Arabia. Annals of Saudi Med. 1990, 10: 598-601.
Google Scholar
Flatz G, Henze HJ, Palabiyikoglu E, Dagalp K, Turkkan T: Distribution of the adult lactase phenotypes in Turkey. Trop Geogr Med. 1986, 38 (3): 255-258.
CAS
PubMed
Google Scholar