Fig. 1

Recurrency of mutations in cancer showing TP53 in pole position

These data were generated by the cBioPortal for Cancer Genomics (https://www.cbioportal.org/) [23, 24]. We selected the PanCancer Studies database and included only the curated set of non-redundant studies in adults, which included 8 different studies with worldwide cases [25,26,27,28,29,30,31,32]. This dataset comprised 25,709 different pan-cancer samples specified by malignant cancer site (anatomical location or topography) and histology (morphology). The piechart shows the number of samples for each study included. Of note, the five most common cancer types were lung adenocarcinoma, colorectal adenocarcinoma, breast carcinoma, pancreatic adenocarcinoma and prostate adenocarcinoma and we displayed in the current figure the top 50 mutated genes. Sequencing data, from the 8 analysed studies, were obtained by using next-generation sequencing (NGS)/targeted sequencing, whole genome paired-end sequencing (WGS), and whole transcriptome/exome paired-end sequencing (WES). For further details about how the data was generated, curated and processed, please see original articles [25,26,27,28,29,30,31,32] and the cBioPortal webpage