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Fig. 4 | BMC Ecology and Evolution

Fig. 4

From: Positive selection-driven fixation of a hominin-specific amino acid mutation related to dephosphorylation in IRF9

Fig. 4

Structural similarities among homologous IRF proteins. a A simplified scheme of the IRF9 domain, showing DBD, a linker region, and IAD; b The nucleotide similarities between IRF9 and other homologous genes. The positively selected site Val129 is shown with a black arrow. The horizontal axis in b indicates CDS coordinates. The vertical axis shows the similarity between IRF9 and its homologs. c The enlarged regional structural alignment of IRF9 and IRF3 around the positively-selected site 129 of human IRF9. The 3D alignment between IRF9 and IRF3 was computed with PyMol v2.5. The 3D structures were based on Alphafold2 modeling

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BMC Ecology and Evolution

ISSN: 2730-7182

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