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Table 1 TLR genome/transcriptome survey results and classification of TLRs included in the phylogenetic analysis

From: The evolution of the metazoan Toll receptor family and its expression during protostome development

Species TLRs V-type/scc P-type/mcc NC References
Cnidaria
 Nematostella vectensis 1 0 1 0 L: [27]
 Acropora digitifera 4 1 3 0 L: [72]
 Acropora millepora 1 0 1 0 L: [72]
 Orbicella faveolata 1 0 1 0 L: [83]
Xenacoelomorpha
 Xenoturbella profunda 0 0 0 0 G: Unpublished
 Hofstenia miamia 0 0 0 0 G: GCA004352715
 Praesagittifera naikaiensis 0 0 0 0 G: PRJDB7329
 Isodiametra pulchra 0 0 0 0 G: Unpublished
 Meara stichopi 0 0 0 0 G: Unpublished
 Convolutriloba macropyga 0 0 0 0 T: [100]
Spiralia
 Bryozoa
  Membranipora membranacea 6 4 1 1 T: SRX1121923
  Bugula neritina 0 0 0 0 T: [101]
 Cycliophora
  Symbion pandora 0 0 0 0 T: [102]
 Annelida
  Galathowenia oculata 39 18 12 9 T: Unpublished
  Eisenia fetida 11 0 1 10 T: SRX3108745
  Helobdella robusta 4 1 3 0 G: [103]
  Phyllochaetopterus prolifica 3 1 0 2 L: [66]
 Mollusca
  Crassostrea gigas 12 10 2 0 G: [104]
  Octopus bimaculoides 9 1 6 2 G: [105]
  Cyclina sinensis 2 1 1 0 L: [88]
  Leptochiton rugatus 1 0 0 1 L: [66]
  Biomphalaria glabrata 27 16 10 1 G: [87]/NCBI
 Brachiopoda
  Terebratalia transversa 15 4 4 7 T: [100]
  Hemithris psittacea 6 3 1 2 T: [66]
  Lingula anatina 25 15 7 3 G: [106]
 Micrognathozoa
  Limnogathia maerski 0 0 0 0 T: SRX1121929
 Gastrotricha
  Lepidodermella squamata 0 0 0 0 T: [107]
  Macrodasys sp 0 0 0 0 T: [108]
  Megadasys sp 0 0 0 0 T: [108]
  Diuronotus aspetos 0 0 0 0 T: SRX1121926
  Mesodasys laticaudatus 0 0 0 0 T: SRX872416
 Nemertea
  Lineus longissimus 10 7 2 1 T: [100]
  Lineus ruber 6 2 3 1 T: Unpublished
  Notospermus geniculatus 7 5 1 1 G: [89]
  Paranemertes peregrina 2 1 0 1 L: [66]
 Phoronida
  Phoronopsis harmeri 2 0 1 1 T: SRX1121914
  Phoronis australis 24 14 8 2 G: [89]
  Phoronis psammophila 3 1 1 1 L: [66]
  Phoronis vancouverensis 6 5 0 1 L: [66]
 Platyhelminthes
  Macrostomum lignano 0 0 0 0 G: [109]
  Echinococcus multilocularis 0 0 0 0 G: [110]
  Hymenolepis microstoma 0 0 0 0 G: [110]
 Rotifera
  Epiphanes senta 1 1 0 0 T: Unpublished
  Rotaria tardigrada 0 0 0 0 T: [111]
  Echinorhynchus gadi 0 0 0 0 T: SRX1121912
  Macracanthorhynchus hirudinaceus 0 0 0 0 T: [108]
Ecdysozoa
 Priapulida
  Priapulus caudatus 3 0 3 0 T: [100]
  Halicryptus spinulosus 4 1 3 0 T: [100]
 Tardigrada
  Hypsibius exemplaris 1 0 1 0 G: [112]
  Ramazzottius varieornatus 1 0 1 0 G: [113]
 Onychophora
  Peripatopsis capensis 1 0 0 1 T: [114]
 Nematoda
  Loa loa 1 0 1 0 G: [115]
  Onchocerca volvulus 1 0 1 0 G: [116]
  Caenorhabditis elegans 1 0 1 0 L: NCBI
 Loricifera
  Armorloricus elegans 2 1 1 0 T: SRX1120677
 Arthropoda
  Daphnia pulex 5 2 3 0 G: [117]
  Drosophila melanogaster 9 1 8 0 L: NCBI
  Ixodes scapularis 5 1 3 1 L: [118]
Deuterostomia
 Tunicata
  Ciona intestinalis 2 1 1 0 L: [97]
  Oikopleura dioica 1 1 0 0 L: [96]
 Echinodermata
  Strongylocentrotus purpuratus 8 7 1 0 L: [64]
 Craniata
  Homo sapiens 10 10 0 0 L: NCBI
  1. NC column indicates the number of TLRs that could not be classified for each species. In the reference column it is indicated whether the survey was performed in a genome (G) or a transcriptome (T), followed by the reference or NCBI accession number in case the genome/transcriptome was published. TLR sequences extracted directly from the literature and, therefore, were not obtained in our genomic and transcriptomic surveys, are indicated with an L. NCBI indicates that sequences were collected individually from NCBI database. For further details, see Additional file 4: Table S2