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Table 1 Some examples of genes in Type I interferon pathways that bear the signature of successive rounds of positive natural selection

From: Positive natural selection in primate genes of the type I interferon response

Category Gene under positive selection Known direct virus interactions Literature showing positive selection
induction MB21D1/cGAS Many classes of viruses Mozzi et al. 2015, Ma et al. 2016
Induction IFI16 HCMV van der Lee 2017, Dell’Oste et al. 2014
Induction ISG15 Influenza Zhao et al. 2013, Zhao et al. 2010
Induction MAVS Hepatitis C virus van der Lee 2017, Anggakusuma et al. 2016
Induction STING Flaviviruses Mozzi et al. 2015, Stabell et al. 2018, Ding et al. 2018
Induction TRIM25 Influenza Malfavon-Borja et al. 2013, Gack et al. 2009
ISG ADAR RNA viruses Forni et al. 2014, Pfaller et al. 2018
ISG MxB Many classes of viruses Mitchell et al. 2015, Haller et al. 2011
ISG EIF2AK2/PKR Influenza Elde et al. 2009, Dauber et al. 2009
ISG RNAse L TMEV van der Lee 2017, Sorgeloos et al. 2013
ISG Tetherin HIV Lim et al. 2010, McNatt et al. 2009
ISG TRIM15 Retroviruses Malfavon-Borja et al. 2013, Uchil et al. 2008
ISG TRIM22 Influenza Sawyer et al. 2007, Di Pietro et al. 2013
ISG TRIM31 Retroviruses Malfavon-Borja et al. 2013, Uchil et al. 2008
ISG TRIM38 Retroviruses Malfavon-Borja et al. 2013, Uchil et al. 2008
ISG TRIM5α HIV Johnson et al. 2009, Sawyer et al. 2005
ISG RSAD2/Viperin RNA viruses Lim et al. 2012, Panayiotou et al. 2018
ISG SAMHD1 HIV-2 Laguette et al. 2012, Coquel et al. 2018