Table 1 TAED gene family lineages with the largest dN/dS values where dS > 0.001

151,766

Boreoeutheria to Laurasiatheria

splicing factor arginine/serine-rich 4/5/6

Herpes simplex infection; Spliceosome

30

Cercopithecidae to Cercopithecidae

transmembrane protein 91 isoform X1

60,787

Euarchontoglires to Simiiformes

fucose-1-phosphate guanylyltransferase

Metabolic pathways; Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism

23,133

Aves to Aves

galanin receptor 1

Neuroactive ligand-receptor interaction

296,346

Eutheria to Delphinidae

LOW QUALITY PROTEIN: probable N-acetyltransferase 16

21,900

Boreoeutheria to Boreoeutheria

X-linked interleukin-1 receptor accessory protein-like 2

52,181

Boreoeutheria to Laurasiatheria

unnamed protein product

8186

Sauria to Anolis carolinensis

protein Simiate

9378

Neognathae to Neognathae

palmitoyltransferase ZDHHC17 isoform X4

22,600

Boreoeutheria to Laurasiatheria

potassium voltage-gated channel subfamily G member 3 isoform X1

4144

Hystricognathi to Hystricognathi

pygopus homolog 1

14,875

Laurasiatheria to Laurasiatheria

kinesin-like protein KIF16B

12,213

Camelidae to Camelus

LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 3

12,593

Boreoeutheria to Boreoeutheria

tRNA (guanine(10)-N2)-methyltransferase homolog

20,708

Amniota to Amniota

heparan sulfate 2-O-sulfotransferase HS2ST1

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

32,532

Boreoeutheria to Carlito syrichta

interleukin 8

AGE-RAGE signaling pathway in diabetic complications; NOD-like receptor signaling pathway;Influenza A; Phospholipase D signaling pathway; Chemokine signaling pathway;Hepatitis B; Toll-like receptor signaling pathway; Legionellosis;RIG-I-like receptor signaling pathway; Rheumatoid arthritis; Malaria; NF-kappa B signaling pathway; Shigellosis;Hepatitis C;N on-alcoholic fatty liver disease (NAFLD); Pathways in cancer; Epithelial cell signaling in Helicobacter pylori infection; Amoebiasis; Bladder cancer; IL-17 signaling pathway; Chagas disease (American trypanosomiasis); Pertussis; Transcriptional misregulation in cancer; Salmonella infection; Cytokine-cytokine receptor interaction

4273

Laurasiatheria to Laurasiatheria

myelin protein zero

Cell adhesion molecules (CAMs)

21,944

Boreoeutheria to Boreoeutheria

adrenergic receptor alpha-2C

cGMP-PKG signaling pathway; Neuroactive ligand-receptor interaction

14,303

Neognathae to Neognathae

ATP-dependent DNA helicase PIF1 partial

14,588

Neognathae to Neognathae

organic solute transporter subunit alpha-like partial

12,299

Neognathae to Neognathae

phosphatidylinositol glycan class H

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways

8762

Myotis to Myotis

doublesex- and mab-3-related transcription factor 2 isoform X1

55,196

Murinae to Mus musculus

Isx protein

14,119

Passeriformes to Passeriformes

cardiolipin synthase CMP-forming

Glycerophospholipid metabolism; Metabolic pathways

39

Boreoeutheria to Boreoeutheria

large subunit ribosomal protein L4e

Ribosome

23,596

Neognathae to Neognathae

diacylglycerol cholinephosphotransferase

Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer; Ether lipid metabolism

10,501

Homo sapiens to Homo sapiens

smoothelin isoform X5

157,103

Neognathae to Haliaeetus albicilla

nucleolar protein 7 partial

3717

Boreoeutheria to Boreoeutheria

glypican 4

Wnt signaling pathway

9725

Eutheria to Boreoeutheria

cilia- and flagella-associated protein 221-like partial