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Table 1 TAED gene family lineages with the largest dN/dS values where dS > 0.001

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

TAED Gene Families with high dN/dS

Family

dN/dS Value

Mapped Location on Chordate Species Tree (Start to End)

Family description

KEGG Pathways

151,766

88.7785

Boreoeutheria to Laurasiatheria

splicing factor arginine/serine-rich 4/5/6

Herpes simplex infection; Spliceosome

30

76.4909

Cercopithecidae to Cercopithecidae

transmembrane protein 91 isoform X1

 

60,787

63.0029

Euarchontoglires to Simiiformes

fucose-1-phosphate guanylyltransferase

Metabolic pathways; Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism

23,133

61.9262

Aves to Aves

galanin receptor 1

Neuroactive ligand-receptor interaction

296,346

55.184

Eutheria to Delphinidae

LOW QUALITY PROTEIN: probable N-acetyltransferase 16

 

21,900

45.0176

Boreoeutheria to Boreoeutheria

X-linked interleukin-1 receptor accessory protein-like 2

 

52,181

44.575

Boreoeutheria to Laurasiatheria

unnamed protein product

 

8186

44.3077

Sauria to Anolis carolinensis

protein Simiate

 

9378

40.3796

Neognathae to Neognathae

palmitoyltransferase ZDHHC17 isoform X4

 

22,600

39.9557

Boreoeutheria to Laurasiatheria

potassium voltage-gated channel subfamily G member 3 isoform X1

 

4144

38.9415

Hystricognathi to Hystricognathi

pygopus homolog 1

 

14,875

38.1267

Laurasiatheria to Laurasiatheria

kinesin-like protein KIF16B

 

12,213

38.0258

Camelidae to Camelus

LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 3

 

12,593

37.1258

Boreoeutheria to Boreoeutheria

tRNA (guanine(10)-N2)-methyltransferase homolog

 

20,708

36.782

Amniota to Amniota

heparan sulfate 2-O-sulfotransferase HS2ST1

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

32,532

36.0215

Boreoeutheria to Carlito syrichta

interleukin 8

AGE-RAGE signaling pathway in diabetic complications; NOD-like receptor signaling pathway;Influenza A; Phospholipase D signaling pathway; Chemokine signaling pathway;Hepatitis B; Toll-like receptor signaling pathway; Legionellosis;RIG-I-like receptor signaling pathway; Rheumatoid arthritis; Malaria; NF-kappa B signaling pathway; Shigellosis;Hepatitis C;N on-alcoholic fatty liver disease (NAFLD); Pathways in cancer; Epithelial cell signaling in Helicobacter pylori infection; Amoebiasis; Bladder cancer; IL-17 signaling pathway; Chagas disease (American trypanosomiasis); Pertussis; Transcriptional misregulation in cancer; Salmonella infection; Cytokine-cytokine receptor interaction

4273

35.4369

Laurasiatheria to Laurasiatheria

myelin protein zero

Cell adhesion molecules (CAMs)

21,944

35.0114

Boreoeutheria to Boreoeutheria

adrenergic receptor alpha-2C

cGMP-PKG signaling pathway; Neuroactive ligand-receptor interaction

14,303

34.6434

Neognathae to Neognathae

ATP-dependent DNA helicase PIF1 partial

 

14,588

34.0198

Neognathae to Neognathae

organic solute transporter subunit alpha-like partial

 

12,299

34.0037

Neognathae to Neognathae

phosphatidylinositol glycan class H

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways

8762

33.6089

Myotis to Myotis

doublesex- and mab-3-related transcription factor 2 isoform X1

 

55,196

31.2663

Murinae to Mus musculus

Isx protein

 

14,119

31.0551

Passeriformes to Passeriformes

cardiolipin synthase CMP-forming

Glycerophospholipid metabolism; Metabolic pathways

39

30.43

Boreoeutheria to Boreoeutheria

large subunit ribosomal protein L4e

Ribosome

23,596

30.0168

Neognathae to Neognathae

diacylglycerol cholinephosphotransferase

Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer; Ether lipid metabolism

10,501

29.8433

Homo sapiens to Homo sapiens

smoothelin isoform X5

 

157,103

27.6427

Neognathae to Haliaeetus albicilla

nucleolar protein 7 partial

 

3717

27.4352

Boreoeutheria to Boreoeutheria

glypican 4

Wnt signaling pathway

9725

26.5684

Eutheria to Boreoeutheria

cilia- and flagella-associated protein 221-like partial