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Table 1 TAED gene family lineages with the largest dN/dS values where dS > 0.001

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

TAED Gene Families with high dN/dS
Family dN/dS Value Mapped Location on Chordate Species Tree (Start to End) Family description KEGG Pathways
151,766 88.7785 Boreoeutheria to Laurasiatheria splicing factor arginine/serine-rich 4/5/6 Herpes simplex infection; Spliceosome
30 76.4909 Cercopithecidae to Cercopithecidae transmembrane protein 91 isoform X1  
60,787 63.0029 Euarchontoglires to Simiiformes fucose-1-phosphate guanylyltransferase Metabolic pathways; Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism
23,133 61.9262 Aves to Aves galanin receptor 1 Neuroactive ligand-receptor interaction
296,346 55.184 Eutheria to Delphinidae LOW QUALITY PROTEIN: probable N-acetyltransferase 16  
21,900 45.0176 Boreoeutheria to Boreoeutheria X-linked interleukin-1 receptor accessory protein-like 2  
52,181 44.575 Boreoeutheria to Laurasiatheria unnamed protein product  
8186 44.3077 Sauria to Anolis carolinensis protein Simiate  
9378 40.3796 Neognathae to Neognathae palmitoyltransferase ZDHHC17 isoform X4  
22,600 39.9557 Boreoeutheria to Laurasiatheria potassium voltage-gated channel subfamily G member 3 isoform X1  
4144 38.9415 Hystricognathi to Hystricognathi pygopus homolog 1  
14,875 38.1267 Laurasiatheria to Laurasiatheria kinesin-like protein KIF16B  
12,213 38.0258 Camelidae to Camelus LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 3  
12,593 37.1258 Boreoeutheria to Boreoeutheria tRNA (guanine(10)-N2)-methyltransferase homolog  
20,708 36.782 Amniota to Amniota heparan sulfate 2-O-sulfotransferase HS2ST1 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
32,532 36.0215 Boreoeutheria to Carlito syrichta interleukin 8 AGE-RAGE signaling pathway in diabetic complications; NOD-like receptor signaling pathway;Influenza A; Phospholipase D signaling pathway; Chemokine signaling pathway;Hepatitis B; Toll-like receptor signaling pathway; Legionellosis;RIG-I-like receptor signaling pathway; Rheumatoid arthritis; Malaria; NF-kappa B signaling pathway; Shigellosis;Hepatitis C;N on-alcoholic fatty liver disease (NAFLD); Pathways in cancer; Epithelial cell signaling in Helicobacter pylori infection; Amoebiasis; Bladder cancer; IL-17 signaling pathway; Chagas disease (American trypanosomiasis); Pertussis; Transcriptional misregulation in cancer; Salmonella infection; Cytokine-cytokine receptor interaction
4273 35.4369 Laurasiatheria to Laurasiatheria myelin protein zero Cell adhesion molecules (CAMs)
21,944 35.0114 Boreoeutheria to Boreoeutheria adrenergic receptor alpha-2C cGMP-PKG signaling pathway; Neuroactive ligand-receptor interaction
14,303 34.6434 Neognathae to Neognathae ATP-dependent DNA helicase PIF1 partial  
14,588 34.0198 Neognathae to Neognathae organic solute transporter subunit alpha-like partial  
12,299 34.0037 Neognathae to Neognathae phosphatidylinositol glycan class H Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways
8762 33.6089 Myotis to Myotis doublesex- and mab-3-related transcription factor 2 isoform X1  
55,196 31.2663 Murinae to Mus musculus Isx protein  
14,119 31.0551 Passeriformes to Passeriformes cardiolipin synthase CMP-forming Glycerophospholipid metabolism; Metabolic pathways
39 30.43 Boreoeutheria to Boreoeutheria large subunit ribosomal protein L4e Ribosome
23,596 30.0168 Neognathae to Neognathae diacylglycerol cholinephosphotransferase Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer; Ether lipid metabolism
10,501 29.8433 Homo sapiens to Homo sapiens smoothelin isoform X5  
157,103 27.6427 Neognathae to Haliaeetus albicilla nucleolar protein 7 partial  
3717 27.4352 Boreoeutheria to Boreoeutheria glypican 4 Wnt signaling pathway
9725 26.5684 Eutheria to Boreoeutheria cilia- and flagella-associated protein 221-like partial