Fig. 4

Schematic representation of the 7 proteases and the 4 agrin-like proteins identified in the proteome of the red coral biominerals. a The peptidase S9 (CR_90) and the matrix metallopeptidase 13 (MMP13, CR_61) are specific to the axial skeleton OM. The cathepsin Z (CR_81) and one MMP12A (CR_64) are specific to the sclerites. The peptidase S8 (CR_30), the other MMP12A (CR_16) and the MMP12B (CR_20) are found in both biominerals. b CR_10, CR_60 and CR_28 are part of the same agrin-1 protein. CR_76, CR_82 and CR_62 are part of the same agrin-2 protein. Proteome ID are indicated, circle representation in the different biominerals fractions is as in Fig. 2b, and protein domains are described in the box. C345C netrin C-terminal domain, DISIN disintegrin domain, EGF-like epidermal growth factor-like, F5/8 type C coagulation factor 5/8 C-terminal domain, FOLN follistatin-N-terminal domain-like, LDLa low-density lipoprotein receptor domain class A, ShK toxin stichodactyla toxin, SP signal peptide, TM transmembrane, TY thyroglobulin type I repeats, WAP four-disulfide core domain