Fig. 2

Distribution of the proteins identified in the organic matrix of the red coral axial skeleton and sclerites. a Among the total 102 proteins identified in the C. rubrum biominerals, 79 are present in the axial skeleton (left) and 75 are present in the sclerites (right), 52 being shared between the two. The Venn diagram shows the number of shared and non-shared proteins between the 4 extracted organic matrices: SOMax: soluble organic matrix of the axial skeleton, IOMax: insoluble matrix of the axial skeleton, SOMsc: soluble organic matrix of the sclerites, and IOMsc: insoluble organic matrix of the sclerites. b Protein domains identified in the proteome of the red coral biominerals and their distribution using circle representation in SOMax (dark blue), IOMax (blue), SOMsc (yellow) and IOMsc (red). ADAM10 desintegrin and metalloproteinase, AMOP adhesion-associated domain present in MUC4 and other proteins, BPI bactericidal permeability-increasing protein/lipopolysaccharide-binding protein/cholesteryl ester transfer protein N-terminal domain, CA carbonic anhydrase, EGF-like epidermal growth factor, EF-hand a calcium-binding domain, F5/8 type C coagulation factor 5/8 C-terminal domain, FAS1 fasciclin-like, HYR hyalin repeat, IG-like immunoglobulin-like, KAZAL serine protease inhibitor, LamG laminin G, LCD low complexity domain, NIDO extracellular domain of unknown function in nidogen, PAM peptidylglycine α-amidating monooxygenase, PHM peptidylglycine α-hydroxylating monooxygenase, ShK toxic stichodactyla toxin, SCP Cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) superfamily proteins, TIMP tissue inhibitor of metalloproteinase, vWA von Willebrand type A, vWD von Willebrand type D, UBA52 Ubiquitin A-52, UOMPs uncharacterized organic matrix proteins, WAP whey acidic protein ‘four-disulfide core’