Fig. 4

Distributions of orthologous groups (OGs) (a) with or without a GO term and (b) with known or unknown high-level KEEG KO category across the pan-genome fractions. Pan-genome fractions: Common core - OGs present in all strains, Common broad core - OGs missing at most in one strain of each species, S. pyogenes core - OGs present in all S. pyogenes strains, S. suis core - OGs present in all S. suis strains, S. pneumoniae core - OGs present in all S. pneumoniae strains, S. pyogenes specific core - OGs present in all S. pyogenes strains and absent in other species, S. suis specific core - OGs present in all S. suis strains and absent in other species, S. pneumoniae specific core - OGs present in all S. pneumoniae strains and absent in other species, S. pyogenes specific periphery - OGs present in some S. pyogenes strains and absent in other species, S. suis specific periphery - OGs present in some S. suis strains and absent in other species, S. pneumoniae specific periphery - OGs present in some S. pneumoniae strains and absent in other species, common periphery - OGs present in some but not all strains of each species, not strain-specific OGs - all OGs excluding singleton OGs, strain-specific OGs - singleton OGs, S. pyogenes periphery - OGs present in some S. pyogenes strains, periphery of S. suis and S. pyogenes - OGs present in some S. suis and S. pyogenes strains,S. suis periphery - OGs present in some S. suis strains, S. pneumoniae periphery - OGs present in some S. pneumoniae strains, periphery of S. pneumoniae and S. suis - OGs present in some S. pneumoniae and S. suis strains, specific core of S. pneumoniae and S. pyogenes - OGs present in all S. pneumoniae and S. pyogenes strains and absent in S. suis strains, periphery of S. pneumoniae and S. pyogenes - OGs present in some S. pneumoniae and S. pyogenes strains, specific core of S. suis and S. pneumoniae - OGs present in all S. suis and S. pneumoniae strains and absent in S. pyogenes strains, specific core of S. suis and S. pyogenes - OGs present in all S. suis and S. pyogenes strains and absent in S. pneumoniae strains