mtProtEvol: the resource presenting molecular evolution analysis of proteins involved in the function of Vertebrate mitochondria

Table 1 Functional enrichment summary of protein-protein interaction network of proteins evolved with accelerated RSA change rate in Primata clade (based on STRING [54] data; see Fig. 6)

Function	Heterotachy model				Heterotachy and Site partitioning models intersection, all data
	All data		Protein structure-aware data
	FDR	Color^a	FDR	Color^a	FDR	Color^a
fatty acid beta-oxidation	0.0001	–	3.9E-05	blue	0.0493	blue
oxidation-reduction process	1.9E-08	red	3.9E-05	yellow	0.0106	red
mitochondrion organization	4.1E-05	violet	0.0002	–	0.0493	green
carboxylic acid catabolism	0.0003	–	3.9E-05	green	0.0493	yellow
carboxylic acid metabolism	3.9E-06	yellow	2.3E-05	red	–	–
single-organism metabolism	2.4E-07	blue	9.0E-05	violet	–	–
small molecule metabolism	0.001	–	0.0002	–	–	–
α-amino acid metabolism	0.009	–	0.0015	–	–	–
cellular respiration	1.0E-06	green	–	–	–	–
negative regulation of RIG-I signaling	0.0102	–	–	–	–	–
mitochondrial transport	0.015	–	–	–	–	–

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