Table 1 The enrichment of the expression shifts between surface fish and cavefish in ASD-risk genes
From: The evolution of a series of behavioral traits is associated with autism-risk genes in cavefish
| Human ASD-risk genes | Cavefish genes | |||||
|---|---|---|---|---|---|---|
| Risk category | # of Listed Genes in Sfari.org | % (#) human ASD-risk genes with cavefish orthologs | % (#) of orthogroups that show significant age × morph interaction† | % (#) of orthogroups that show significant expression difference between morphs at 72 hpf† | % (#) of all paralogs that show significant age × morph interaction† | % (#) of all paralogs that show significant expression difference between morphs at 72 hpf† |
| Category 1 | 19 |
94.7% (18 of 19) |
72.2% (13 of 18) |
94.4% (17 of 18) |
61.1% (> 99.9 percentile) (22 of 36) |
75.0% (> 99.9 percentile) (27 of 36) |
| Category 2 | 43 |
93.0% (40 of 43) |
65.0% (26 of 40) |
67.5% (27 of 40) |
60.7% (> 99.9 percentile) (34 of 56) |
64.3% (> 99.9 percentile) (36 of 56) |
| Category 3 | 139 |
95.0% (132 of 139) |
60.6% (80 of 132) |
70.5% (93 of 132) |
50.3% (84.8 percentile) (95 of 189) |
58.2% (> 99.9 percentile) (110 of 189) |
| Category 4 | 244 |
89.8% (219 of 244) |
62.6% (137 of 219) |
63.0% (138 of 219) |
51.9% (96.1 percentile) (167 of 322) |
52.5% (94.4 percentile) (169 of 322) |
| Category S (not already included among Cat 1–4 genes) | 48 |
97.9% (47 of 48) |
57.4% (27 of 47) |
63.8% (30 of 47) |
44.2% (4.7 percentile) (34 of 77) |
49.4% (59.0 percentile) (38 of 77) |
| Total | 493 |
92.5% (456 of 493 human genes) |
62.1% (283 of 456) |
66.9% (305 of 456) |
53.8% (352 of 654) |
54.6% (357 of 654) |
| Bootstrapping score: mean ± 95% confidence interval | 48.0 ± 4.2% | 49.0 ± 4.4% | ||||