Table 1 The enrichment of the expression shifts between surface fish and cavefish in ASD-risk genes
From: The evolution of a series of behavioral traits is associated with autism-risk genes in cavefish
Human ASD-risk genes | Cavefish genes | |||||
|---|---|---|---|---|---|---|
Risk category | # of Listed Genes in Sfari.org | % (#) human ASD-risk genes with cavefish orthologs | % (#) of orthogroups that show significant age × morph interaction† | % (#) of orthogroups that show significant expression difference between morphs at 72 hpf† | % (#) of all paralogs that show significant age × morph interaction† | % (#) of all paralogs that show significant expression difference between morphs at 72 hpf† |
Category 1 | 19 | 94.7% (18 of 19) | 72.2% (13 of 18) | 94.4% (17 of 18) | 61.1% (> 99.9 percentile) (22 of 36) | 75.0% (> 99.9 percentile) (27 of 36) |
Category 2 | 43 | 93.0% (40 of 43) | 65.0% (26 of 40) | 67.5% (27 of 40) | 60.7% (> 99.9 percentile) (34 of 56) | 64.3% (> 99.9 percentile) (36 of 56) |
Category 3 | 139 | 95.0% (132 of 139) | 60.6% (80 of 132) | 70.5% (93 of 132) | 50.3% (84.8 percentile) (95 of 189) | 58.2% (> 99.9 percentile) (110 of 189) |
Category 4 | 244 | 89.8% (219 of 244) | 62.6% (137 of 219) | 63.0% (138 of 219) | 51.9% (96.1 percentile) (167 of 322) | 52.5% (94.4 percentile) (169 of 322) |
Category S (not already included among Cat 1–4 genes) | 48 | 97.9% (47 of 48) | 57.4% (27 of 47) | 63.8% (30 of 47) | 44.2% (4.7 percentile) (34 of 77) | 49.4% (59.0 percentile) (38 of 77) |
Total | 493 | 92.5% (456 of 493 human genes) | 62.1% (283 of 456) | 66.9% (305 of 456) | 53.8% (352 of 654) | 54.6% (357 of 654) |
Bootstrapping score: mean ± 95% confidence interval | 48.0 ± 4.2% | 49.0 ± 4.4% | ||||