Table 4 Genes/proteins from the TBEVHostDB that had four pairwise interactions with the other genes/proteins within the network
The central gene/protein | Dataset/Type of evidence | Number of neighbors | Neighbors | Biological role of subnetwork |
|---|---|---|---|---|
IFNAR1 | Up- or down-regulated | 4 | TYK2, PEPD, IFNB1, IFNA2 | Attenuation of interferon signaling pathway by viral protein NS5 targeting PEPD |
CCR5 | Allelic variant | 4 | CD4, CCL3, CCL4, CCL2 | The entry of TBEV into the host cell/The proinflammatory and tissue damage pathway |