Fig. 6
From: Conservation and diversification of small RNA pathways within flatworms
Endogenous RNA interference pathway genes detected in flatworms. The non-coding RNA (ncRNA) containing a dsRNA region is transcribed in the nucleus and processed in the cytoplasm by ERI complex. After binding, the ncRNA ERI-1 removes one of unpaired strands creating a hairpin structure suitable for priming the synthesis of long dsRNA by RRF-3. Dicer and DRH-3 then, cleave the long dsRNA, and ERGO-1 (homologous to Ago2 in D. melanogaster) loaded with siRNA triggers the target RNA degradation. Endogenous RNAi pathway factors with homologous genes detected in flatworms are indicated (“Flatworm Distribution Code” box). A ‘shape’ code was used to indicate predicted function of factors (“Protein Function Code” box)