Fig. 4

Comparison of the homologous genome regions harbouring the human ANGPTL8 with the fish and lizard. The gene environment of the human ANGPTL8 gene was characterised and was used to identify homologous genes in the Anole lizard and several fish: the coelacanth (lobed-finned fish), the spotted gar (ray-finned fish), the elephant shark (cartilaginous fish) and the marine lamprey (jawless fish) genomes. Horizontal lines represent the chromosome fragments; arrow boxes indicate genes and the arrowhead points in the direction of the predicted gene transcription. Only genes that were conserved across species are represented. Gene names are indicated according to the human annotation and the same colour is used for gene homologues and they are presented according to their order in the chromosome. The size of the genome fragments analysed and the predicted location of the genes in the chromosomes are indicated in Megabase pairs. Gene names and symbols are: Coactivator-Associated Arginine Methyltransferase 1 (CARM1), Low Density Lipoprotein Receptor (LDLR), KN Motif and Ankyrin Repeat Domains 2 (KANK2), Dedicator Of Cytokinesis 6 (DOCK6), Member RAS Oncogene Family (RAB3D), Transmembrane Protein 205 (TMEM205), Coiled-Coil Domain Containing 159 (CCDC159), Lipid Phosphate Phosphatase-Related Protein Type 2 (LPPR2) and SWIM-Type Zinc Finger 7 Associated Protein 1 (SWSAP1)