Fig. 2

Distribution of positions composing stress-related patterns in p53 TAD2 and TD/RD: a Patterns that are more frequent in species included in the “hypoxic” (red)/“metabolic” (green) “-stress” groups relative to those included in the “non-stress” (blue) group. Residues composing the patterns are marked in bold-red (LLXXE in TAD2, KXXGE and LM in TD/RD). An additional pattern was more frequent only for the “hypoxic-stress” species relative to “non-stress species” (LLXXEXXA in TAD2), marked in bold red and black; b Pattern identified in all “hypoxic-stress” species and in none of the species included in either the “metabolic-” or “non-” “stress” groups. This pattern is a combination of two motifs: [DE]LLX[ST] (bold red) and [DE]XX[AV]XWL (bold black)