Fig. 1

Schematic representation of data used in the study a Balanced experimental design. Phylogenetic tree showing the evolutionary relationships between pairs of hypoxia-tolerant and hypoxia-sensitive species. Red lines represent hypoxia-tolerant species. The hypoxia tolerant species were paired with their closest hypoxia-sensitive phylogenetic relative, which has an available p53 sequence; b Diagram of p53 domains (human p53). P53 domains include: transactivation subdomain 1 (TAD1), transactivation subdomain 2 (TAD2), proline-rich domain (PRD), DNA binding domain (DBD), nuclear localization signal (NLS), and tetramerization and regulatory domains (TD/RD). Domain lengths are in blue, amino-acid positions are in black, and domain names are in red