Codon usage is associated with the evolutionary age of genes in metazoan genomes

Table 2 Partition of D. melanogaster genes into age groups

a
D. melanogater gene is in Age group:	If the furthest species containing a homologue is among:
1	*D. melanogaster, D. sechellia, D. simulans, D. erecta, D. yakuba*
2	D. ananassae
3	D. pseudoobscura, D. persimilis
4	D. wilistoni
5	D. mojavensis, D. grimshawi, D. virilis
6	Ades aegypti., Anopheles gambiae.
7	Vertebrates, C. elegans
8	Saccharomyces cerevisiae
b
Age group	# genes	Coding region GC content		Protein length
		Mean	SD	Mean	SD
1	336	0.49	± 0.06	412	± 892
2	130	0.49	± 0.06	401	± 406
3	160	0.49	± 0.06	394	± 245
4	147	0.51	± 0.06	456	± 421
5	2582	0.54	± 0.06	568	± 691
6	1841	0.55	± 0.05	650	± 625
7	3155	0.55	± 0.04	578	± 471
8	2632	0.55	± 0.04	543	± 406
Total	10983

Partition of all genes in D. melanogaster into 8 non-overlapping age groups along the evolutionary tree. (a) Genes were divided into 8 age groups. The 6 youngest groups (1 to 6) are a "high-resolution" partition, enabled by the recent sequencing of 12 members of the Drosophilidae family and 2 mosquito species. (b) For each age group, the number of genes it contains, its average GC content (with standard deviation), and the average length of proteins (number of amino acids/codons analyzed) that its genes encode (with standard deviation) are listed.

ISSN: 2730-7182