Table 1 Proteins implicated in the Notch pathway and their known functions
From: Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes
Component type/role | Component name and abbreviation |
|---|---|
Receptor | Notch |
Ligands | Delta/Jagged |
Fucosyltransferase | O-fucosyltransferase (O-fut) |
Glycosyltransferase | Fringe |
Cleavage S1 | Furin |
Cleavage S2 | ADAM 17 = TACE |
Metalloproteases | ADAM 10 = Kuzbanian |
Cleavage S3 | Presenilin (Pres) |
| Â | Nicastrin |
γ-secretase complex | Anterior Pharynx defective 1 (APH1) |
| Â | Presenilin Enhancer 2 (PEN2) |
Transcriptional complex | CSL (CBF1, Su(H), Lag-1) |
| Â | Silencing Mediator of Retinoid and Thyroid receptors (SMRT) |
Targets | Hairy Enhancer of Split (HES) |
Ligand | Neuralized (Neur) |
Regulation | Mindbomb (Mib) |
Receptor | Deltex |
Regulation | NEDD4/Suppressor of Deltex (Su(dx)) |
| Â | Mastermind (MAM) |
| Â | Numb |
| Â | Notchless (Nle) |
| Â | Strawberry notch (Sno) |