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Archived Comments for: The genome sequence of the protostome Daphnia pulexencodes respective orthologues of a neurotrophin, a Trk and a p75NTR: Evolution of neurotrophin signaling components and related proteins in the bilateria

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  1. Musks are the vertebrate NRK orthologue

    Wayne Sossin, McGill University

    19 November 2009

    In the manuscript it is stated that there are no deuterostome orthologues of the Nrk family. However, we had earlier pointed out that the Nrk family is orthologous to the deuterostome Musk family (Sossin, 2006 BBE 68:145-156). The Musk family, despite its close similarity to Rors and Trks was not examined in this manuscript.

    Competing interests


  2. Clarification on NRKs

    Karen Wilson, University of Gothenburg , The Sven Lovén Centre for Marine Sciences -Kristineberg, S-450 34 Fiskebäckskil, Sweden

    19 November 2009

    In the manuscript, NRKs refer to Drosophila melanogaster NRK orthologues lacking, like Drosophila melanogaster NRK, an "NPxY" adaptor sequence prior to the tyrosine kinase domain. NRKs have however been shown to be orthologues of the Musk family of RTKs in deuterostomes (Sossin WS, 2006: Brain Behav Evol.; 68(3):145-56).

    Competing interests

    No competing interests.