Functional divergence between SAP30 and SAP30L. a) A neighbor-joining tree of the tetrapodan/sarcopterygian SAP30 and SAP30L, and the arthropodan SAP30L, showing the jackknife values at the nodes. The monophyletic tetrapodan/sarcopterygian SAP30 cluster is shaded. The curved arrows indicate comparisons for type-I (θI) and type-II (θII) functional divergence, and statistically significant p-values are indicated. b) Posterior probability plot of amino acid positions indicative of type-I or type-II functional divergence. The conserved domains are depicted in the white boxes between the plots. Zn = zinc dependent module, PIP = monophosphoinositide binding motif, N = nucleolar lozalization signal, P = protein-protein interaction domain.