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Table 4 Amino acid changes associated with the divergence of human bestrophins

From: Molecular evolution and functional divergence of the bestrophin protein family

Comparison Codon position in human Best1a Codon position and amino acid residueb Codon position and amino acid residueb Protein domainc
Best1 vs. Best4   in vertebrate Best1 in vertebrate Best4  
  264 264: Y, conserved 279: P, Q, S, L, E, G or Y Loop 3
  265* 265: P, conserved 280: A, T, Q, E or K Loop 3
  266 266: G, conserved 281: L, A, V, P, K, E or D Loop 3
  267 267: H, conserved 282: G, W, P or H Loop 3
  331* 331: R, P, V, I, L or M 346: P, conserved C-terminus
  343 343: P, conserved 358: P, A, F or V C-terminus
  349 349: A, conserved 364: V, I, L, P, Q or A C-terminus
Best2 vs Best4   in vertebrate Best2 in vertebrate Best4  
  45* 45: A, conserved 45: V, L, M, F or T TMD2
  52* 52: F, conserved 52: L, K, R, C or F Loop 1
  59 59: K, conserved 59: R, K or Q Loop 1
  61* 61: Y, conserved 61: V, I, L, M or E Loop 1
  66 66: V, A or S 66: A, conserved Loop 1
  91 91: N or H 91: N, conserved Loop 2
  106 106: L or V 106: L, conserved Loop 2
  132 132: A, S or C 132: A, conserved Loop 2
  206 206: A, T or S 206: A, conserved Loop 2
  207* 207: L, F or Y 207: L, conserved Loop 2
  263* 263: G, conserved 263: G, E, A or P Loop 3
  264 264: Y, conserved 279: P, E, Q, G, S or Y Loop 3
  331 331: V, M or P 346: P, conserved C-terminus
  349 349: A, conserved 364: V, P, Q, L or A C-terminus
Best3 vs Best4   in vertebrate Best3 in vertebrate Best4  
  60* 60: R, conserved 60: Y, H, R, S or D Loop 1
  115 115: H, Q, R or L 115: H, conserved Loop 2
  209* 209: S, T, M or N 209: L, conserved Loop 2
  264 264: Y, conserved 279: P, Q, S, L, E, G or Y Loop 3
  266 266: G, conserved 281: L, V, E, P, K, D or A Loop 3
  331 331: K or R 346: P, conserved C-terminus
Best2 vs Best3   in vertebrate Best2 in vertebrate Best3  
  165* 165: R, conserved 165: T, A, P, S or R Loop 2
  268 268: D, T, S or N 268: D, conserved Loop 3
  333 333: E, conserved 333: K, R, E, A, N or T C-terminus
  354* 354: Q, L, D or V 354: Y, conserved C-terminus, AI domain
  365 366: D, conserved 365: Q, D, E or H C-terminus, AI domain