Figure 3

Patterns of altered evolutionary constraints on different functional categories. Four clusters of functional categories obtained by hierarchical clustering with characteristic deviations from the genome-wide divergence-DAF distributions are shown. For each cluster, a representative 3 × 3 normalized divergence-DAF matrix (left), 3 × 1 coding GERP matrix (middle) and signature of constraints (right) are provided. Representative matrices are the average of the patterns of all functional categories within the cluster, across all populations. The colour codes of the divergence-DAF matrix and coding GERP matrix are same as in Figure 2C. Signatures of constraints are as in Figure 1. Only functional categories for which signatures are significant in at least three out of four HapMap populations (without Bonferroni correction) are shown. Individual patterns of divergence-DAF matrices for all these functional categories in each population are shown in Additional File 4.