The role of positive selection in determining the molecular cause of species differences in disease

Table 2 Interacting clusters formed between PSGs on each lineage

Cluster number	Genes in cluster	pvalue for cluster size given previous clusters	pvalue for cluster given number of interactions per gene **
Chimpanzee
1	PCSK5, BMP4, PHOX2A	0.981	0.0013
2	LHB, OTX1, JUB	0.391	0.0001
3	XPC, RAD23A	0.519	0.0035
4	NUCB1, PTGS1	0.346	0.0046
5	ITGB6, ALOX12	0.227	0.0030
6	MYO18A, TRADD	0.131	0.0028
7	GSTP1, MAP2K4	0.075	0.0442
8	PEX12, PEX19	0.036*	0.0003
9	NRP1, MSI1	0.019*	0.0008
Dog
1	CFP, TAL1, SERPINB1, MMP12, PRF1, BCL2, HRG, ITGA5, COMP	0.385	< 0.0001
2	CD79A, HCLS1, LCP2	0.209	0.0012
3	SNTA1, DAG1, MUSK	0.036*	0.0002
4	LRP5, SLC2A2	0.171	0.0026
5	ALB, MCAM	0.082	0.0123
Hominid
1	CCL19, CD86, MADCAM1	0.335	0.0015
2	MRC2, COL4A4	0.186	0.0028
3	DRD2, TH	0.045*	0.0488
4	ITGAV, AZGP1	0.008*	0.0080
Mouse
1	HLA-DRB1, HLA-DQA2	0.755	0.0123
2	C1R, C1QA	0.288	0.0030
Murid
1	TLR5, CD86, PTGIR	0.678	0.0001
2	SCNN1G, SPTA1, HECW1	0.432	0.0021
3	CNR1, RAPGEF1	0.190	0.0110
4	F5, GP1BA	0.064	0.0032
Rat
1	CDKN2D, TRIM21, CDKN1B, CAST, ICAM1, CFD, ITGB2, C3	0.360	< 0.0001
2	KCNA4, ACTN2, PIK3R5	0.526	0.0016
3	PIM1, RP9	0.280	0.0063
4	ASPH, HDAC4	0.118	0.0053

*p < 0.05.
** All tests to investigate if the size of the cluster would be more than expected by chance given the number of interactors each individual gene in that cluster were significant (p < 0.05).

ISSN: 2730-7182