Mammalian RFX DBDs are highly conserved. DBDs from six mammalian RFX genes were aligned using ClustalW. The conservation of amino acid is depicted by a color gradient from the color yellow, which indicates low conservation, to red, which indicates high conservation. Nine residues that make direct or water-mediated DNA contacts are indicated with arrow heads. The species names included in this figure are abbreviated. They are: Mus–mouse (Mus musculus); Rno–Rat (Rattus norvegicus); Cfa–dog (Canis familiaris); Ptr–chimpanzee (Pan troglodytes); Mmu–monkey (Macaca mulatta) and Hsa–human (Homo sapiens).