GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals

Table 3 Sequence identity analysis

		Xenopus Laevis			Gallus gallus			Mododelphis domestica			Mus musculus			Homo sapiens
		MT1	MT2	Mel1c GPR50	MT1	MT2	Mel1c GPR50	MT1	MT2	Mel1c GPR50	MT1	MT2	Mel1c GPR50	MT1	MT2	Mel1c GPR50
Xenopus laevis	MT1
	MT2	55
	Mel1c GPR50	59	71
Gallus gallus	MT1	62	71	70
	MT2	57	82	68	69
	Mel1c GPR50	56	73	79	69	72
Monodelphis domestica	MT1	57	65	67	78	68	71
	MT2	38	50	64	67	71	68	61
	Mel1c GPR50	54	72	56	54	53	57	54	53
Mus musculus	MT1	58	43	67	78	68	66	75	64	55
	MT2	55	65	62	60	65	61	56	65	48	58
	Mel1c GPR50	38	63	46	52	51	46	48	51	45	53	45
Homo sapiens	MT1	59	64	70	80	69	70	77	61	54	83	59	50
	MT2	54	70	64	59	69	61	59	69	49	61	82	48	61
	Mel1c GPR50	39	44	49	50	52	52	49	48	47	52	47	71	51	50

Percentages of amino acid identity between MT1, MT2, and Mel1c/GPR50 sequences from five species, Xenopus laevis, Gallus gallus, Monodelphis domestica, Mus Musculus, and Homo sapiens All the sequences were compared with a Smith-Waterman local alignment software [57]. All the results ranged from 38% (Xl-MT1 vs Mm-GPR50) to 83% (Mm-MT1 vs Hs-MT1) of identity. The percentage of identity between protein sequences of paralogous genes ranged from 50% (Hs-MT2 vs Hs-GPR50) to 72% (Gg-MT2 vs Gg-Mel1c). The percentage of identity between protein sequences of orthologous genes ranged from 45% (Md-GPR50 vs Mm-GPR50) to 83% (Mm-MT1 vs Hs-MT1).
Percentages of identity between sequences encoded by orthologous genes are written in bold.
Percentages of identity between sequences encoded by paralogous genes are written in italic.

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