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Table 3 Sequence identity analysis

From: GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals

   Xenopus Laevis Gallus gallus Mododelphis domestica Mus musculus Homo sapiens
   MT1 MT2 Mel1c GPR50 MT1 MT2 Mel1c GPR50 MT1 MT2 Mel1c GPR50 MT1 MT2 Mel1c GPR50 MT1 MT2 Mel1c GPR50
Xenopus laevis MT1                
  MT2 55               
  Mel1c GPR50 59 71              
Gallus gallus MT1 62 71 70             
  MT2 57 82 68 69            
  Mel1c GPR50 56 73 79 69 72           
Monodelphis domestica MT1 57 65 67 78 68 71          
  MT2 38 50 64 67 71 68 61         
  Mel1c GPR50 54 72 56 54 53 57 54 53        
Mus musculus MT1 58 43 67 78 68 66 75 64 55       
  MT2 55 65 62 60 65 61 56 65 48 58      
  Mel1c GPR50 38 63 46 52 51 46 48 51 45 53 45     
Homo sapiens MT1 59 64 70 80 69 70 77 61 54 83 59 50    
  MT2 54 70 64 59 69 61 59 69 49 61 82 48 61   
  Mel1c GPR50 39 44 49 50 52 52 49 48 47 52 47 71 51 50  
  1. Percentages of amino acid identity between MT1, MT2, and Mel1c/GPR50 sequences from five species, Xenopus laevis, Gallus gallus, Monodelphis domestica, Mus Musculus, and Homo sapiens All the sequences were compared with a Smith-Waterman local alignment software [57]. All the results ranged from 38% (Xl-MT1 vs Mm-GPR50) to 83% (Mm-MT1 vs Hs-MT1) of identity. The percentage of identity between protein sequences of paralogous genes ranged from 50% (Hs-MT2 vs Hs-GPR50) to 72% (Gg-MT2 vs Gg-Mel1c). The percentage of identity between protein sequences of orthologous genes ranged from 45% (Md-GPR50 vs Mm-GPR50) to 83% (Mm-MT1 vs Hs-MT1).
  2. Percentages of identity between sequences encoded by orthologous genes are written in bold.
  3. Percentages of identity between sequences encoded by paralogous genes are written in italic.