Figure 1

Genomic organization of the two fugu protocadherin loci ( FrPcdh1 and FrPcdh2 ). White boxes represent variable exons whereas solid bars at the end of each cluster represent the constant exons. The dotted line in FrPcdh2γ cluster represents a gap in the sequence. The IDs and position of the BAC and cosmid clones, as well as the relevant scaffolds, are shown below the gene clusters. The names of variable exons after the gap carry a prime sign (γ24' to γ37') to indicate that the numbers may not reflect their actual positions in the locus. The non-Pcdh flanking genes and their orientation at each end of the locus are indicated by arrows. fPcd1: protocadherin 1 (a non-clustering protocadherin gene with multiple coding exons), fFlj31436: a homolog of human hypothetical protein FLJ31436, fHrh2: histamine receptor H2, fKcnip1: Kv channel interacting protein 1, fEtf1: eukaryotic translation termination factor 1, fFbxw11: F-box and WD-40 domain protein 1B, fFgf18: fibroblast growth factor 18, fDiaph1: diaphanous 1, fTrpc7: transient receptor potential cation channel, subfamily C, member 7.