Figure 1

Overview of the predicted transmembrane arrangement of the Neurospora mitochondrial porin across the mitochondrial outer membrane. The model takes into account several secondary structure predictions, and experimental probing of the structure in artificial bilayers through the use of point mutations [14], deletions [9, 15, 16], and site-specific biotinylation [13], as described in [16]. The predicted N-terminal α-helix is represented by a cylinder, and putative β-strands by zig-zag lines, and loops and β-turns by curved arrows. The arrowheads point in the direction of the C-terminus of the protein.