Time course of fitness effects of different mutation types and pathway size. Fitness effects of each mutation type are averaged over the entire population. Data is collected and averaged over seven different runs of a simulation where the ratio of protein recruitment probability over the sum of interaction formation and protein recruitment probabilities was 0.5 (same data as in Figure 6). Different colors indicate different mutation types. Using the notation of Figure 6 we have; black for "Protein Duplication", red for "Coefficient Change", blue for "Protein Loss", green for "Interaction Formation", cyan for "Protein Recruitment", and yellow for "Interaction Loss".