Figure 5
From: High variability and non-neutral evolution of the mammalian avpr1a gene
Sliding window analysis of the ratio of non-synonymous substitutions (dN) over synonymous substitutions (dS) along the avpr1a gene of mammals compared to the marsupial Monodelphis domestica (see text). The ratio is drawn over the midpoint window position (window size 30, step size 10) from nucleotide position 50 to 800 from the start codon (due to primer selection). dN/dS exceeds 1 in the ligand binding domain, which indicates positive selection in this region. A second peak of dN/dS close to 1 is found around 750 bp corresponding to the G-protein binding domain of the AVP 1a receptor.