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Table 2 ATPase score motif associated with the C-terminal tail of tanabin, transitin and nestin of different species by Conserved domain database analysis on the NCBI server. An ATPase motif was detected in tanabin, transitin and nestin in comparison with the domain architectures available in the Conserved domain database on the NCBI server. The score shown in the table is calculated using PSSM scoring matrix based on protein alignment. The expected value is also given for each alignment and significant E-values for this database searching are considered to be > 10-5. Protein sequences for this analysis were obtained from sequenced genomes available on NCBI and JGI genome assembly v4.1. Tanabin-xt: 186291, chicken transitin: X80877, dog predicted-nestin: XP_547531.2, mouse nestin: NP_057910.3, rat nestin: NP_037119.1 and human nestin: NM_006617

From: Molecular evolution of type VI intermediate filament proteins

Query sequence

E-value (IF domain)

E-value (ATPase domain)

Tanabin (Xenopus laevis) gi|549051

2e-15

0.00031

Transitin (Gallus gallus) gi|45384298

5e-14

5e-152

Nestin3 (Canis familiaris) gi|73961547

6e-8

2e-81

Nestin3 (Monodelphis domestica) gi|126307847

3e-19

0.0000091

Nestin3 (Bos taurus) gi|76612380

9e-13

No hits

Nestin (Rattus norvegicus) gi|6981262

7e-11

0.0081

Nestin (Mus musculus) gi|50363232

0.000002

0.0032

Nestin3 (Macaca mulatta) gi|109017378

9e-13

No hits

Nestin (Homo sapiens) gi|1346682

9e-7

0.000042

  1. 1 NCBI imported model COG5271, MDN1, AAA ATPase containing von Willebrand factor type A domain
  2. 2 NCBI imported model COG1196, Smc, Chromosome segregation ATPases
  3. 3 Predicted sequence