Table 1 TRAPP subunit conservation:
From: Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex
S. cerivisiae Subunit (#amino acids)1 | Human Subunit (# amino acids)1 | Essential in S. cerivisiae | Comments1 |
|---|---|---|---|
TRAPP I/II: | Â | Â | Â |
Bet3 (193) | hBet3/TRAPPC3 (180) | + | Bet3 family2 |
Trs31 (283) | TRAPPC5 (188) | + | Bet3 family2 |
Trs33 (268) | TRAPPC6 A&B (173, 130) | -- | Bet3 family2 |
Bet5 (159) | TRAPPC1/MUM2 (145) | + | Bet5 family2 Expression of Ag peptides in melanoma |
Trs20 (175) | TRAPPC2/SEDL (140) | + | Bet5 family2 Associated w/bone formation & SEDT |
Trs23 (219) | TRAPPC4/Synbindin (219) | + | Bet5 family2 Associated with postsynaptic structures |
Trs85/Gsg1 (698) | -- | -- | Required for late sporulation, vt autophagy pathway in S. cerivisiae |
TRAPP II: | Â | Â | Â |
Trs120 (1289) | NIBP (1246) | + | 21% identity in 377 match length; Implicated in NF-kappaB signaling, & neuro-degenerative disorders |
Trs130 (1102) | TMEM1/EHOC1 (1259) | + | 20% identity in 327 match length; Proposed similarity to sodium channels; Candidate for certain epilepsy and autoimmune disorders |
Trs65/Kre11 (560) | -- | -- | Important for cell wall biogenesis in S. cerivisiae |