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Table 5 Most frequent Pfam-A families/superfamilies in protein sequences that are associated with single or multiple functions

From: Tracing the origin of functional and conserved domains in the human proteome: implications for protein evolution at the modular level

Fa

Pb

Tc

Most abundant families/superfamilies (Top 10)

   

Description

Nd

1

11,646

1,778

Immunoglobulin superfamily (Ig)

598

   

Zinc finger family (Zf-C2H2)

348

   

Protein kinase superfamily (Pkinase)

339

   

FAD/NAD(P)-binding Rossmann fold Superfamily (NADP_Rossmann)

191

   

Ankyrin repeat

151

   

RNA recognition motif (RRM_1)

130

   

Major Facilitator Superfamily (MFS)

114

   

Ig-like fold superfamily (E-set)

112

   

Peptidase clan PA

106

   

Methyltransferase superfamily

104

2

4,933

1,333

Zinc finger family (Zf-C2H2)

477

   

Kruppel-associated box

326

   

Immunoglobulin superfamily (Ig)

322

   

Marek's disease glycoprotein A

206

   

WD-40 repeats (beta-transducin repeats)

167

   

Protein kinase superfamily (Pkinase)

160

   

Ig-like fold superfamily (E-set)

150

   

IKI3 family

149

   

FAD/NAD(P)-binding Rossmann fold Superfamily

124

   

POZ domain superfamily

99

3

2,229

965

G-protein superfamily

166

   

G-protein alpha subunit

136

   

Dynein light intermediate chain

132

   

Immunoglobulin superfamily (Ig)

113

   

WD-40 repeats (beta-transducin repeats)

104

   

Zinc finger family (Zf-C2H2)

98

   

IKI3 family

96

   

Keratin, high sulfur B2 protein

96

   

Protein kinase superfamily (Pkinase)

93

   

Zinc finger, C3HC4 type (Ring finger)

90

4

1,038

678

Immunoglobulin superfamily (Ig)

90

   

Atrophin-1

84

   

Keratin, high sulfur B2 protein

83

   

Class II histocompatibility antigen, beta domain

77

   

Class I histocompatibility antigen, domain alpha 1 and 2

77

   

Extensin-like region

71

   

Giardia variant-specific surface protein

67

   

Class I histocompatibility antigen, C- terminus

66

   

P-loop containing nucleoside triphosphate hydrolase superfamily

57

   

Family A G protein-coupled receptor-like superfamily

56

5

1,136

536

Frizzled/OA1/CAR/Secretin receptor-like superfamily

676

   

Family A G protein-coupled receptor-like superfamily

675

   

Mammalian taste receptor protein

664

   

C. elegans chemosensory receptor

660

   

C.elegans Srg family integral membrane protein

659

   

Atrophin-1

97

   

Keratin, high sulfur B2 protein

92

   

Giardia variant-specific surface protein

77

   

Extensin-like region

63

   

Dentin matrix protein 1

53

  1. a F = Number of functions associated with a protein sequence
  2. b P = Number of protein sequences associated with F number of functions
  3. c T = Number of unique Pfam-A families associated with P number of protein sequences
  4. d N = Frequency of a Pfam-A family in P number of protein sequences
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BMC Ecology and Evolution

ISSN: 2730-7182

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