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Table 5 Most frequent Pfam-A families/superfamilies in protein sequences that are associated with single or multiple functions

From: Tracing the origin of functional and conserved domains in the human proteome: implications for protein evolution at the modular level

Fa Pb Tc Most abundant families/superfamilies (Top 10)
    Description Nd
1 11,646 1,778 Immunoglobulin superfamily (Ig) 598
    Zinc finger family (Zf-C2H2) 348
    Protein kinase superfamily (Pkinase) 339
    FAD/NAD(P)-binding Rossmann fold Superfamily (NADP_Rossmann) 191
    Ankyrin repeat 151
    RNA recognition motif (RRM_1) 130
    Major Facilitator Superfamily (MFS) 114
    Ig-like fold superfamily (E-set) 112
    Peptidase clan PA 106
    Methyltransferase superfamily 104
2 4,933 1,333 Zinc finger family (Zf-C2H2) 477
    Kruppel-associated box 326
    Immunoglobulin superfamily (Ig) 322
    Marek's disease glycoprotein A 206
    WD-40 repeats (beta-transducin repeats) 167
    Protein kinase superfamily (Pkinase) 160
    Ig-like fold superfamily (E-set) 150
    IKI3 family 149
    FAD/NAD(P)-binding Rossmann fold Superfamily 124
    POZ domain superfamily 99
3 2,229 965 G-protein superfamily 166
    G-protein alpha subunit 136
    Dynein light intermediate chain 132
    Immunoglobulin superfamily (Ig) 113
    WD-40 repeats (beta-transducin repeats) 104
    Zinc finger family (Zf-C2H2) 98
    IKI3 family 96
    Keratin, high sulfur B2 protein 96
    Protein kinase superfamily (Pkinase) 93
    Zinc finger, C3HC4 type (Ring finger) 90
4 1,038 678 Immunoglobulin superfamily (Ig) 90
    Atrophin-1 84
    Keratin, high sulfur B2 protein 83
    Class II histocompatibility antigen, beta domain 77
    Class I histocompatibility antigen, domain alpha 1 and 2 77
    Extensin-like region 71
    Giardia variant-specific surface protein 67
    Class I histocompatibility antigen, C- terminus 66
    P-loop containing nucleoside triphosphate hydrolase superfamily 57
    Family A G protein-coupled receptor-like superfamily 56
5 1,136 536 Frizzled/OA1/CAR/Secretin receptor-like superfamily 676
    Family A G protein-coupled receptor-like superfamily 675
    Mammalian taste receptor protein 664
    C. elegans chemosensory receptor 660
    C.elegans Srg family integral membrane protein 659
    Atrophin-1 97
    Keratin, high sulfur B2 protein 92
    Giardia variant-specific surface protein 77
    Extensin-like region 63
    Dentin matrix protein 1 53
  1. a F = Number of functions associated with a protein sequence
  2. b P = Number of protein sequences associated with F number of functions
  3. c T = Number of unique Pfam-A families associated with P number of protein sequences
  4. d N = Frequency of a Pfam-A family in P number of protein sequences