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Table 3 Analysis of markers common to 4 species

From: Recurring genomic breaks in independent lineages support genomic fragility

Minimum Flank

Fixed species

# blocks

Variable species 1 (# breaks)

Variable species 2 (# breaks)

#joint breaks (β

Avg #joint breaks in shuffles

p-value of correlated break (βp)

2

hg,mus

403240

canis(741)

rn(1067)

17

10.4

0.025

2

hg,rn

394250

canis(709)

mus(451)

9

3.7

0.009

2

canis,mus

380087

hg(352)

rn(982)

5

5.7

0.677

2

canis,rn

369584

hg(332)

mus(383)

2

1.6

0.453

3

hg,mus

406346

canis(599)

rn(858)

16

7.5

0.006

3

hg,rn

394036

canis(566)

mus(311)

9

2.4

0

3

canis,mus

378865

hg(303)

rn(797)

5

4.4

0.423

3

canis,rn

364549

hg(283)

mus(257)

2

1.1

0.31

  1. For Rank differential = 2, the table shows the number of breaks in the variable species, the number of joint breaks, the average number of joint breaks in 1000 random shuffles and the p-value of the joint breaks, for FBP. This is based on greater than 500 bps markers common to Human, Mouse, Rat, and Dog. 4 of the 8 combinations have significant joint breaks.