Figure 7

Probabilistic approach in calculating the effective replication accuracy with epistasis (a) The probability that a mutant is neutral with v neutral substitutions and δ deleterious substitutions (i.e., μ(v, δ)) is plotted against the number of neutral substitutions (v). Symbols: ● δ = 0; □ δ = 1; ◇ δ = 2; ○ δ = 3; * δ = 4. The plots were obtained from the same data set as that of Fig. 5. The solid lines represent the results of curve fitting. We used Eq. 10 (v>0, δ = 0) to the δ = 0 data set, and Eq. 10 (v>0, δ>0) to the δ = 1 data set. The second fitting was done after we obtained α and ε _n from the first fitting, and ε _d and η from the fitting in Fig. 7b. The dotted lines are the estimation made with the obtained parameters (listed below). (b) μ(v, δ) plotted against the number of deleterious substitutions (δ). Symbols: ● v = 0; □ v = 1; ◇ v = 2; ○ v = 3; * v = 4. The solid part of the line represents the curve fitting; the dotted part is an exception, i.e., μ(0, 1) = 0. We used Eq. 10 (v = 0, δ>0) toward the v = 0 data set in the fitting. All the fitting was done after transforming both the equations and the data sets to logarithmic scale to reduce the biased importance of the points in small d. The obtained parameters are as follows: ε _n = 0.1190, α = 0.8483, ε _nd = 2.418, β = 2.333, γ = 3.996, ε _d = 0.02697 and η = 0.6380.