Coiled-coil protein composition of 22 proteomes – differences and common themes in subcellular infrastructure and traffic control

Table 4 Clusters with sequences from prokaryotes and eukaryotes

Cluster size (# of sequences)	Max. edge (P-score)	protein family	putative function/site of action	organisms represented
45	4.6E-7	Structural maintenance of chromosomes 1–4	condensin, cohesin (chromatin)	A.f., A.t., A.tu., B.b., B.s., C.e., C.v., D.m., H.s., M.g., M.j., M.m., M.t., O.s., S.c., S.p, S.sp., T.a.
26	1.6E-10	Ser/Thr-kinases (DAP, DMK, GIN4, ROCK)	signal transduction	C.e., D.m., H.s., M.m., O.s., S.c., S.sp.

Numbers include "bridge" sequences qualifying for more than one cluster. Only clusters represented by at least 10 sequences are listed. DAP, death-associated protein kinase [119]; DMK, myotonic dystrophy kinase [120]; GIN4, growth inhibitory gene 4 [121]; ROCK, Rho-associated coiled-coil containing kinase [114]. For species name abbreviations, see Table 1.

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