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Table 5 Phosphorylation sites predictions for human sirtuins

From: Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

 

NetPhos

Group based prediction system (GPS)

Phosphosite

 

N-term

Core

C-term

N-term

Core

C-term

N-term

Core

C-term

SIRT1

13(27%)

5(10%)

30(63%)

20(25%)

10(13%)

50(62%)

8(38%)

1(5%)

12(57%)

SIRT2

5(22%)

11(48%)

7(30%)

8(18%)

28(62%)

9(20%)

3(33%)

2(22%)

4(45%)

SIRT3

8(50%)

7(44%)

1(6%)

11(35%)

17(55%)

3(10%)

0(0%)

2(100%)

0(0%)

SIRT4

1(11%)

8(89%)

0(0%)

5(18%)

23(82%)

0(0%)

0(0%)

2(100%)

0(0%)

SIRT5

4(29%)

10(71%)

0(0%)

5(19%)

21(78%)

1(03%)

0(0%)

4(100%)

0(0%)

SIRT6

2(11%)

11(58%)

6(31%)

4(11%)

25(66%)

9(23%)

1(13%)

1(13%)

6(74%)

SIRT7

5(19%)

16(62%)

5(19%)

6(13%)

31(65%)

11(22%)

0(0%)

0(0%)

0(0%)

  1. We report the prediction obtained by Netphos and GPS. Phosphosite was used as additional reference, though it contains few data about sirtuins. GPS is specific for human sirtuins. In the rows are indicated the total number of phosphosites for segment and in parenthesis the percentage on the total number of phosphosites in the given protein.