Figure 4

Exclusion of currency metabolites by maximizing effective modularity. Effective modularity (ΔQ; y-axis) is maximized by iteratively removing common metabolites (x-axis). The dashed horizontal line indicates the line corresponding to the ΔQ based on 1000 randomizations of the full network (ΔQ = 0). The vertical line corresponds to the number of metabolites excluded when the network modularity is maximized. A) When compartmental designations are included for each metabolite the ΔQ for the network is maximized after the 24 most frequently occurring metabolites are removed. B) When compartmental designations are not included for each metabolite the ΔQ for the graph is maximized after the 20 most frequently occurring metabolites are removed. C) Results of modularity maximization for the individual cellular compartments.