Table 1 List of species included in this study

Homo sapiens

Mus musculus ^a

Rattus norvegicus ^a

Gallus gallus ^a

Xenopus tropicalis ^a

Danio rerio ^a

Takifugu rubripes

Ciona intestinalis

Anopheles gambiae ^a

Drosophila melanogaster

Apis mellifera ^a

Caenorhabditis briggsae ^a

Caenorhabditis elegans

Monosiga brevicollis

Saccharomyces cerevisiae ^a

Candida glabrata

Ashbya gossypii ^a

Kluyveromyces lactis

Debaryomyces hansenii

Yarrowia lipolytica

Magnaporthe oryzae ^a

Neurospora crassa ^a

Fusarium oxysporum ^a

Aspergillus fumigatus

Schizosaccharomyces pombe

Cryptococcus neoformans

Ustilago maydis ^a

Encephalitozoon cuniculi

Dictyostelium discoideum

Entamoeba dispar ^a

Entamoeba histolytica

Arabidopsis thaliana

Oryza sativa

Populus trichocarpa

Physcomitrella patens

Chlamydomonas reinhardtii

Volvox carteri

Ostreococcus lucimarinus ^a

Cyanidioschyzon merolae

Guillardia theta ^b

Bigelowiella natans ^b

Emiliania huxleyi ^c

Theileria parva

Plasmodium berghei ^a

Plasmodium falciparum

Plasmodium knowlesi ^a

Plasmodium vivax ^a

Plasmodium yoelii ^a

Toxoplasma gondii

Cryptosporidium hominis ^a

Cryptosporidium parvum

Paramecium tetraurelia

Tetrahymena thermophila

Phaeodactylum tricornutum

Thalassiosira pseudonana

Phytophthora infestans

Leishmania braziliensis ^a

Leishmania infantum ^a

Leishmania major

Trypanosoma brucei

Trypanosoma cruzi ^a

Trypanosoma vivax ^a

Naegleria gruberi

Giardia lamblia

Trichomonas vaginalis