Figure 4

Multiple sequence alignment of the LNX3 homology domain. An alignment prepared using ClustalX of the last 150 amino acids of murine LNX3, LNX4 and LNX5 as well as LNX3/4 orthologs from diverse invertebrate species. Sequence conservation is plotted beneath the alignment and conserved residues marked and color coded according to the default CustalX settings. A Jnet secondary structure prediction for LNX3 was generated using the alignment and is shown on top (E = extended or beta sheet conformation, H = helical). Amino acids numbers for mouse LNX3 are indicated. Mm = Mus musculus; Sp = S. pupuratus; Sk = S. kowalevskii; Bf = B. floridae; Am = Apis mellifera; Tc = Tribolium castaneum; Ce = C. elegans; Dm = D. melanogaster; Sm = S. mansoni; Hm = H. magnipapillata