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Table 4 Comparison of the accessible surface area (ASA) values of atypical amino acid replacement sites with those of all sites in gapless alignments

From: Molecular evolution of cyclin proteins in animals and fungi

  Skewness of atypical replacement samples to positions in the protein globule
  Interior positions in globule (p)* Surface positions in globule (p)*
Cyclin families DSSP ASA values 10 ASA
classes
3 ASA
classes
DSSP ASA values 10 ASA
classes
3 ASA
classes
A animal 0.9966 0.9957 0.9906 0.0034 0.0043 0.0095
B animal 0.9570 0.9772 0.9678 0.0432 0.0230 0.0324
B fungal 0.6029 0.7785 0.7500 0.3983 0.2224 0.2512
B3 animal 0.9914 0.9975 0.9827 0.0087 0.0025 0.0175
D animal 0.9713 0.9200 0.8835 0.0289 0.0805 0.1173
E animal 0.9995 0.9999 0.9999 0.0005 0.0001 0.0001
  1. *Distribution skewness was estimated using one-tailed Mann-Whitney's test.
  2. p ≤ 0.005 is in bold, 0.005 <p ≤ 0.025 is in italics; Bonferonni's correction for simultaneous testing of two statistical hypotheses based on the same dataset: accessible surface area and atypical amino acid replacements positions.