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Table 4 Mutation spectrum at centromeres is unlike that of gene conversion

From: Evidence for a high mutation rate at rapidly evolving yeast centromeres

Study Ts: Tv Ts:Tv freq 1 bp deletions Del:BPS freq 1 bp insertions Other
CDEII 46: 68 0.68 4 0.047 0 18a
Genome-wide (WT) 12: 19 0.63 1 0.032 0 1
URA3 Lang (WT) 46: 121 * 0.38 22 0.017 3 15
CAN1 Lang (WT) 65: 85 0.76 56 0.034 8 13
URA3 Hicks (WT) 19: 27 0.70 5 0.014 1 9
URA3 Hicks (GC) 32: 24 * 1.33 32 0.074 1 14
  1. The mutation spectrum of CDEII is compared to the wild type spontaneous mutation (WT) inferred from various studies (Genome-wide, [15]; Lang, [23]; Hicks, [13]), and the mutation spectrum expected under gene conversion (GC, [13]). "Other" indicates indels that are -> 1 bp long, and in the case of CDEII also includes indels occurring in homopolymer runs that were 5 bp or longer (N = 14), other mutations described as "Other" for the WT and GC datasets are described in [13]. The deletion: base pair subsitution frequency (Del:BPS) corrects for the difference in target length at which deletions could be observed compared to the target length for base pair substitutions ([23], e.g. for URA3, indel target size = 804 bp, and BPS target size = 104 bp). For CDEII the number of deletions (N = 4) was compared to the number of base pair substitutions (N = 84) outside homopolymer runs. * Significantly different from CDEII (Fisher's exact test, P < 0.05). Poisson tests showed that none of the Del:BPS frequencies were significantly different from that of CDEII.