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Table 2 Number of genes in each functional class with evidences of adaptive selection

From: Genetic adaptation of the antibacterial human innate immunity network

Functional Class   Africans Europeans
  N Positive Selection Balancing Selection Positive Selection Balancing Selection
Receptors 19 TLR2 LY96 LY64a, TLR9, TLR10a CD14, LY96, TLR6
Adaptors 10 - - IRAK4 a -
Modulators 6 SOCS2a, TOLLIP - - -
Acute Phase 20 - LTA, IL18RAP, IL1F5, IL1F7 IL18BP a IL1F5, IL1A, IL1F10, IL18RAP, IL1F7
Cellular Immunity 10 - - - -
Antiinf. Cytokines 10 - - TGFB2 -
Neutrophil 9 IL17B a - - -
Chemokines 14 IL8 a - CCR4 -
Extracellular 6 - - ADAM33 -
Complement 8 - CFH, C5, C3 - C3
Effector 15 MPO, NGFR NTRK1 MPO ITGA8
Non classified 5 CTNNB1 - TNFRSF18 -
  1. N, number of genes in each functional category.
  2. a Genes with evidences of positive selection showing an excess of derived alleles at high frequencies (Fay and Wu's H test).