Phylogeny of SH3+GUK domain sequences. The topology and branch lengths were obtained by maximum likelihood analysis performed in raxml. The tree is rooted in the branch between the MPP and the DLG+DLG-like clades. Statistical support obtained by 100-bootstrap raxml replicates, 100-bootstrap phyml replicates, and bayesian posterior probability is shown for the main clades. The canonical domain architecture is shown for each MAGUK class.