Figure 5

Modulation of [³H]dopamine uptake by β-PEA in brain striatal synaptosomes. Synaptosomes from wild-type mouse (n = 3), TAAR1 knockout mouse (n = 3) and dog (n = 1) were exposed to 10 nM [³H]dopamine alone or 10 nM [³H]dopamine plus 100 nM β-PEA for the indicated times. Uptake values are percentage of the maximal uptake. Note the reduction in dopamine uptake during β-PEA challenge in wild-type mouse as compared to TAAR1 knockout mouse and dog. Data are presented as mean ± S.E.M.