Figure 6

Synteny and paralogy around the Otx gene family. Map positions of amphioxus Otx and its neighbouring genes are compared to their human orthologues, which map primarily to chromosomes 1, 2, 14, 11 and 19, not chromosome 3. Amphioxus genes are shown in their physical order, and are numbered as in amphioxus (B. floridae) genome assembly v. 1.0. GeneID 20 is amphioxus Otx. GeneID 22 and 23 are most likely two parts of a gene and are treated as one locus. Human orthologues are not necessarily in order. Amphioxus genes 2 and 19 (black boxes) do not have clear human homologues; phylogenetic relationships are not well resolved for amphioxus genes 8, 17 and 24 (grey boxes). Human orthologues of amphioxus gene 13 do not map to on the five main chromosomal regions.