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Table 2 The presence of TVV and mycoplasmas in analysed strains of Trichomonas vaginalis and their susceptibility to metronidazole.

From: Concordance between genetic relatedness and phenotypic similarities of Trichomonas vaginalis strains

Strain TVV mycoplasmas Patient response to treatment MLC at 48 hours (metronidazole μg.ml-1)* (aerobic conditions)
     Geometric mean Range n
IR78 - - Refractory 107.2 50–200 20
TV 79–49 + - Cured 1.92 1.56–6.5 10
TV 71–96 + + Cured 3.35 3.125–6.25 10
FF28 + - Cured 2.14 1.56–3.125 11
TALL-MT - - Refractory 3.125 3.125 10
CP1 - - Cured 2.01 0.78–6.25 11
JH31A - - Cured 3.85 1.56–6.25 11
C-1:NIH + - Cured 1.56 1.56 6
JTCRYO - - Cured 2.50 1.56–3.125 6
TV 10–02 + + Cured 4.7 3.125–12.5 36
TV 14–85 - + Cured 9.9 6.25–12.5 36
TV 73–87 + + Cured 3.12 3.12 12
TV 67–77 - + Cured 12.5 12.5 12
TV 85–08 + - Cured 6.25 6.25 12
BO + - Refractory 50 50 12
HL-4MT - - Refractory 317.5 200–400 36
TV 7–37 - - Cured 20.83 12.5–25 36
CDC-85 - - Refractory† 1000† not available not available
TV 17–48 - - Cured 12.5 12.5 3
RU357 - - Refractory† 200 † not available not available
  1. * Minimal lethal concentrations (MLC) for metronidazole were determined by in vitro microtitre plate assay [32] under aerobic conditions. MLC was defined as the lowest concentration of metronidazole at which no motile parasites were detectable by microscopy. † Drug-susceptibility data for strains CDC-85 and RU 357 were obtained from literature [34].